Document Detail


Protection against tetanus in the aged people in the Czech Republic--cross-sectional study.
MedLine Citation:
PMID:  15680496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aged people belong to most vulnerable group for tetanus infection in terms of their vaccination history, frequency of injuries, which may serve as gate of entry for this infection and declared decrease of general as well as specific immunity. The examinations of the aged people for antitetanus antibodies have been done to assess the immunity against tetanus in this particular group of people in the Czech republic. Blood samples were collected from people living in hostels for senior citizens on the bases of signed informed consent. The study focused on people older than 60 years of age. TETANUS ELISA Genzyme Virotech GmbH kit was used for detection of IgG antibodies against tetanus. The level of >0.1 IU/ml was used as protective level of antibodies. Total number of 341 samples was investigated for antibodies against tetanus. Nonprotective (<0.1 IU/ml) titer of antibodies was found in 9.1% of subjects and 90.9% of people possessed protective titers of antibodies against tetanus. The interval between the last vaccination (or revaccination) against tetanus and collection of blood sample was ascertained in 257 subjects and this interval was 10 years or less in 89.9% of subjects. Geometric mean of titers was calculated for different intervals between the last vaccination and collection of blood sample. There was an increasing trend of geometric mean values found with decreasing interval from the last vaccination. But there were also good values of geometric mean of titers found in subjects vaccinated long before collection of blood (intervals up to 27 years). Due to completely different situation in the Czech Republic, where adult people were repeatedly revaccinated in military service (males), in the employment with higher risk of tetanus infection, in context with treatment of injuries and finally during mass vaccination campaigns, organized in the Czech Republic for all adult people in 1974-1976 and in 1984-1986, even the aged people can reach acceptable immunity against tetanus.
Authors:
Vladimir Janout; Ivanka Matouskova; Lucie Machova; Ludek Cizek; Gabriela Janoutova; Jana Hoskova
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of gerontology and geriatrics     Volume:  40     ISSN:  0167-4943     ISO Abbreviation:  Arch Gerontol Geriatr     Publication Date:    2005 Mar-Apr
Date Detail:
Created Date:  2005-01-31     Completed Date:  2005-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214379     Medline TA:  Arch Gerontol Geriatr     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  123-8     Citation Subset:  IM    
Affiliation:
Department of Preventive Medicine, Faculty of Medicine, Palacky University Olomouc, Hnevotínská 3, 775 15 Olomouc, Czech Republic. janout@tunw.upol.cz
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Antibodies, Bacterial / blood*
Clostridium tetani / immunology*
Cross-Sectional Studies
Czech Republic
Enzyme-Linked Immunosorbent Assay / methods
Female
Housing for the Elderly
Humans
Immunoglobulin G / blood*
Male
Middle Aged
Regression Analysis
Tetanus / immunology*,  prevention & control
Time Factors
Vaccination*
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin G

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