| Protection against reactive oxygen species by selenoproteins. | |
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MedLine Citation:
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PMID: 19268692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reactive oxygen species (ROS) are derived from cellular oxygen metabolism and from exogenous sources. An excess of ROS results in oxidative stress and may eventually cause cell death. ROS levels within cells and in extracellular body fluids are controlled by concerted action of enzymatic and non-enzymatic antioxidants. The essential trace element selenium exerts its antioxidant function mainly in the form of selenocysteine residues as an integral constituent of ROS-detoxifying selenoenzymes such as glutathione peroxidases (GPx), thioredoxin reductases (TrxR) and possibly selenoprotein P (SeP). In particular, the dual role of selenoprotein P as selenium transporter and antioxidant enzyme is highlighted herein. A cytoprotective effect of selenium supplementation has been demonstrated for various cell types including neurons and astrocytes as well as endothelial cells. Maintenance of full GPx and TrxR activity by adequate dietary selenium supply has been proposed to be useful for the prevention of several cardiovascular and neurological disorders. On the other hand, selenium supplementation at supranutritional levels has been utilised for cancer prevention: antioxidant selenoenzymes as well as prooxidant effects of selenocompounds on tumor cells are thought to be involved in the anti-carcinogenic action of selenium. |
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Authors:
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Holger Steinbrenner; Helmut Sies |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-03-05 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1790 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-19 Completed Date: 2010-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1478-85 Citation Subset: IM |
Affiliation:
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Institute for Biochemistry and Molecular Biology I, Heinrich-Heine-University, D??sseldorf, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytoprotection / drug effects, genetics* Humans Neoplasms / prevention & control Neuroprotective Agents / metabolism Reactive Oxygen Species / pharmacology* Selenium / pharmacology, therapeutic use Selenoproteins / genetics, metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Neuroprotective Agents; 0/Reactive Oxygen Species; 0/Selenoproteins; 7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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