| Protection against lipid peroxidation induced during preservation of lungs for transplantation. | |
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MedLine Citation:
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PMID: 7865534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The questions of whether oxygen-derived free radicals are induced during preservation of lungs and, if so, how such radicals might relate to reperfusion injury were investigated by means of an isolated canine lung model. Lungs were obtained from 16 mongrel dogs and divided into groups 1 (n = 6), 2 (n = 5), and 3 (n = 5). The lungs of groups 1, 2, and 3 were flushed through the pulmonary artery with Euro-Collins solution alone, the solution with superoxide dismutase (120,000 U/L), and the solution with allopurinol (1 mmol/L), respectively, at 4 degrees C and then stored for 4 hours in the respective solutions at 4 degrees C with clamped bronchi. They were then reperfused for 2 hours by means of an isolated lung model. Lung lipid peroxidation was sequentially determined. The lung functional status was assessed by systolic pulmonary arterial pressure and end-inspiratory airway pressure. The lung edema was assessed by lung wet/dry weight ratio. Lipid peroxidation was induced after 1 hour of preservation and the first 30 minutes of the reperfusion in group 1 and only 2 hours of the reperfusion in group 2, whereas no induction was observed in group 3. Values for systolic pulmonary arterial pressure and end-inspiratory pressure in group 1 were significantly higher than those in group 3 (p < 0.05). The lung wet/dry weight ratio in group 1 was significantly higher than that in groups 2 and 3 (p < 0.05). The present results indicate that the administration of free radical scavengers in the preservation may effectively improve conditions for lung transplantation. |
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Authors:
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K Nezu; K Kushibe; T Tojo; N Sawabata; K Kawachi; Y Mizumoto; D Nakae; Y Konishi; S Kitamura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 13 ISSN: 1053-2498 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 1994 Nov-Dec |
Date Detail:
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Created Date: 1995-03-28 Completed Date: 1995-03-28 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 998-1002 Citation Subset: IM |
Affiliation:
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Department of Surgery III, Nara Medical College, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance Allopurinol / pharmacology Animals Blood Pressure Dogs Free Radicals Hypertonic Solutions / pharmacology Lipid Peroxidation* Lung / metabolism* Lung Transplantation* Organ Preservation* Pulmonary Artery / physiopathology Superoxide Dismutase / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Euro-Collins' solution; 0/Free Radicals; 0/Hypertonic Solutions; 315-30-0/Allopurinol; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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