Document Detail

Protection against cisplatin lethality and renal toxicity by chlorpromazine in mice.
MedLine Citation:
PMID:  7899579     Owner:  NLM     Status:  MEDLINE    
The effect of chlorpromazine on acute lethal toxicity and nephrotoxicity induced by cisplatin was studied in mice. Chlorpromazine (i.p.) given 1 h before cisplatin greatly reduced lethal and renal toxicities of cisplatin, while chlorpromazine did not reduce the antitumor activity of cisplatin against sarcoma 180 in ddY mice or El-4 leukemia in C57BL/6J mice.
M Ishikawa; M Ozaki; Y Takayanagi; K Sasaki
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Renal failure     Volume:  16     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-04-25     Completed Date:  1995-04-25     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  681-6     Citation Subset:  IM    
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
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MeSH Terms
Chlorpromazine / pharmacology*
Cisplatin / therapeutic use,  toxicity*
Disease Models, Animal
Drug Therapy, Combination
Kidney / drug effects*
Kidney Failure / chemically induced,  prevention & control*
Lethal Dose 50
Mice, Inbred C57BL
Nitrogen / urine
Sarcoma 180 / drug therapy
Reg. No./Substance:
15663-27-1/Cisplatin; 50-53-3/Chlorpromazine; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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