Document Detail


Protection against cis-diamminedichloroplatinum-induced nephrotoxicity by 2,3-dimercaptosuccinic acid in rats.
MedLine Citation:
PMID:  10586422     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was designed to examine the usefulness of 2,3-dimercaptosuccinic acid (DMSA) for the purpose of reducing cis-diamminedichloroplatinum (DDP)-induced nephrotoxicity and effective clinical use of DDP and safe. The effectiveness of DMSA on the DDP-excretion in rat kidney was observed by measuring the platinum concentration using Atomic Absorption Instrument. Co-administration of DMSA (1.0 or 2.0 mmol/kg) 1 hour after DDP injection (20 mumol/kg) showed more decrease in the platinum concentration than that immediately after DDP injection. The alleviating effect of DMSA on DDP toxicity was evaluated by lipid peroxidation, enzymatic antioxidants, and glutathione levels. The administration of DDP alone caused a significant increase in lipid peroxidation and significant decreases in enzymatic antioxidants and glutathione levels in the kidney. Co-administration of DMSA (2.0 mmol/kg) 1 hour after DDP injection showed the most effective reduction of these enzymatic damages caused by DDP. These findings suggested that the co-administration of DMSA (2.0 mmol/kg) 1 hour after DDP injection leads DDP to effective excrete from renal tissue and suppresses the lipid peroxide reaction and results in reduction of nephrotoxicity.
Authors:
K Mishima; S Hidaka; N Takamura; S Shinozawa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  21     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-21     Completed Date:  1999-12-21     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  593-602     Citation Subset:  IM    
Affiliation:
Department of Pharmacy, Miyazaki Medical College Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / metabolism
Chelating Agents / pharmacology*
Cisplatin / pharmacokinetics,  toxicity*
Glutathione / metabolism
Kidney / drug effects*,  metabolism
Lipid Peroxidation / drug effects
Male
Rats
Rats, Wistar
Succimer / pharmacology*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Chelating Agents; 15663-27-1/Cisplatin; 304-55-2/Succimer; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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