Document Detail


Protection against carbon tetrachloride-induced hepatotoxicity by pretreatment with methylmercury hydroxide.
MedLine Citation:
PMID:  1129809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pretreatment of rats with methylmercury hydroxide (MMH) (15 mg/kg s.c. for 2 days) protected against hepatotoxicity due to the inhalation of CCl4 vapor (4800-6100 ppm for 2 h). This was evidenced by lessening of the changes due to CCl4 in liver glucose-6-phosphatase, serum glutamic oxalacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum isocitrate dehydrogenase and serum sorbitol dehydrogenase. Decreases in p-nitroanisole demethylation and cytochrome P-450 were also altered. Lipid peroxidation due to CCl4 was decreased by MMH. These biochemical indices of protection were supported by histopathological observations. These results lend further support to the concept that metabolism of CCl4 is necessary for its hepatoxicity.
Authors:
G P Carlson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Toxicology     Volume:  4     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1975  
Date Detail:
Created Date:  1975-08-04     Completed Date:  1975-08-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Tetrachloride Poisoning / pathology,  prevention & control*
Drug-Induced Liver Injury / pathology,  prevention & control*
Lipid Metabolism
Liver / enzymology,  pathology
Male
Methylmercury Compounds / therapeutic use*
Microsomes, Liver / enzymology
Rats
Chemical
Reg. No./Substance:
0/Methylmercury Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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