Document Detail


Protection against acute toxicity of acetaldehyde in mice.
MedLine Citation:
PMID:  769119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of several compounds to protect against acetaldehyde-induced loss of righting reflex was studied in mice and compared with previously published results in rats. L-cysteine (3 mMoles/kg), L-ascorbic acid, DL-thioctic acid, or DL-homocysteine (2 mMoles/kg each) was administered orally 30 minutes prior to an intraperitoneal ED90 of acetaldehyde (415 mg/kg). Cysteine, ascorbate, and thioctic acid caused a statistically significant reduction in acetaldehyde-induced toxicity, while homocysteine afforded only little protection. These results are qualitatively, but not quantitatively, similar to those reported for rats.
Authors:
P J O'Neill; R G Rahwan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  13     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-05-20     Completed Date:  1976-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  125-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetaldehyde / antagonists & inhibitors*
Animals
Ascorbic Acid / pharmacology
Cysteine / pharmacology
Male
Mice
Reflex / drug effects
Thioctic Acid / pharmacology
Chemical
Reg. No./Substance:
50-81-7/Ascorbic Acid; 52-90-4/Cysteine; 62-46-4/Thioctic Acid; 75-07-0/Acetaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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