| Protection against acoustic trauma by direct application of D-methionine to the inner ear. | |
| | |
MedLine Citation:
|
PMID: 21480759 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Abstract Conclusion: The findings from this study extend the use of the local application of D-methionine (D-met) to protect against acoustic trauma and demonstrate that D-met slowly diffuses from the perilymph. Objectives: The objectives of the study were to determine the effect of D-met on auditory function and morphology after acoustic trauma and to measure the concentration of D-met in perilymph. Methods: Auditory thresholds were determine before, immediately after, and 24 h after acoustic trauma. Cochleae were analyzed using immunocytochemistry for c-Fos, TUJI, and cytochrome c. The concentration of D-met was determined from perilymph. Results: Protection against acoustic trauma (immediately and 24 h post trauma) on auditory brainstem thresholds was found at a time when the concentration of D-met in perilymph showed a fivefold increase above basal levels. The local application of D-met to the guinea pig cochlea results in elevated D-met concentrations that are maintained in the perilymph for at least 24 h. |
| | |
Authors:
|
Zlatan Alagic; Michel Goiny; Barbara Canlon |
Related Documents
:
|
14523449 - Role of visual pigment properties in rod and cone phototransduction. 2614369 - Membrane current responses of skate photoreceptors. 15223829 - Dark adaptation of rod photoreceptors in normal subjects, and in patients with stargard... 20884499 - Combination of rod and cone inputs in parasol ganglion cells of the magnocellular pathway. 9797939 - Evidence for a noise gain control mechanism in human vision. 6268219 - Light-induced changes of cyclic gmp content in frog retinal rod outer segments measured... 20166159 - Phototoxicity is not associated with photochemical tissue bonding of skin. 18339559 - Spatio-temporal characteristics of low-frequency bold signal fluctuations in isoflurane... 15845249 - Attenuation of perceived motion smear during the vestibulo-ocular reflex. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-11 |
Journal Detail:
|
Title: Acta oto-laryngologica Volume: - ISSN: 1651-2251 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral admi...
Next Document: Potential Pitfalls and Therapeutic Implications of Pretherapeutic Radiologic Staging in Glottic Canc...