Document Detail

Protection afforded by a herbal medicine, Sho-seiryu-to (TJ-19), against oleic acid-induced acute lung injury in guinea-pigs.
MedLine Citation:
PMID:  19589235     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The effect of a herbal medicine, Sho-seiryu-to (TJ-19), on oleic acid-induced lung injury, an animal model of acute respiratory distress syndrome or acute lung injury (ARDS/ALI), was examined. METHODS: Acute lung injury was induced by an intravenous injection of 15 microl/kg oleic acid to guinea-pigs. TJ-19 was administered by a single oral dose (3 g/kg) or by multiple oral doses (0.75 g/kg). KEY FINDINGS: The decrease in partial oxygen pressure of arterial blood (Pao(2)) and the increase in airway vascular permeability induced by the oleic acid injection were attenuated by a single dose of TJ-19. When TJ-19 was administered orally twice a day for two weeks and then oleic acid was injected, a potent prophylactic effect of the drug was observed. TJ-19 also prevented airway vascular hyperpermeability, lung cell injury, oxidative stress and thromboxane A(2) generation, associated with the oleic acid injection. CONCLUSIONS: TJ-19 significantly attenuated the oleic acid-induced lung injury probably through the antioxidative effect and inhibitory effect of thromboxane A(2) generation, although the precise inhibitory mechanisms were not fully elucidated due to the diversity in constituents of the herbal medicine. We suggest that TJ-19 is a promising drug candidate and a medicinal resource for preventing ARDS/ALI.
Chang-Qing Yang; Yoichi Ishitsuka; Hiroshi Moriuchi; Saeid Golbidi; Zhen-Ji Jin; Mitsuru Irikura; Tetsumi Irie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  61     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-10     Completed Date:  2009-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  925-32     Citation Subset:  IM    
Department of Pharmaceutical Sciences, College of Pharmacy, Yanbian University, Yanji, China.
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MeSH Terms
Acute Lung Injury / chemically induced,  prevention & control*
Capillary Permeability / drug effects
Disease Models, Animal
Drugs, Chinese Herbal / pharmacology,  therapeutic use*
Guinea Pigs
Herbal Medicine
Oleic Acid
Oxidative Stress / drug effects
Plants, Medicinal
Thromboxane A2 / antagonists & inhibitors,  biosynthesis
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/sho-seiryu-to; 112-80-1/Oleic Acid; 57576-52-0/Thromboxane A2

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