Document Detail

Protection of mouse heart against hypoxic damage by AMP deaminase inhibition.
MedLine Citation:
PMID:  20544535     Owner:  NLM     Status:  MEDLINE    
Clinical observation in patients with heart disease indicates that reduced activity of AMP deaminase could be protective in heart failure and ischemic heart disease. This study evaluated the effect of 3-[2-(3-carboxy-4-bromo-5,6,7,8-tetrahydronaphthyl)ethyl]-3,6,7,8-tetrahydroimidazo [4,5-d][1,3]diazepin-8-ol, an AMP deaminase inhibitor (AMPDI) in the mouse heart subjected to hypoxia. ApoE/LDLR knock-out mice were subjected to reduced oxygen tension in breathing air. AMPDI was infused before hypoxia in the treated group. We observed amelioration of elcetrocardiographic changes during hypoxia in the treated group that are consistent with a protective effect.
T Borkowski; E M Slominska; C Orlewska; S Chlopicki; P Siondalski; M H Yacoub; R T Smolenski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nucleosides, nucleotides & nucleic acids     Volume:  29     ISSN:  1532-2335     ISO Abbreviation:  Nucleosides Nucleotides Nucleic Acids     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892832     Medline TA:  Nucleosides Nucleotides Nucleic Acids     Country:  England    
Other Details:
Languages:  eng     Pagination:  449-52     Citation Subset:  IM    
Department of Biochemistry, Medical University of Gdansk, Poland.
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MeSH Terms
AMP Deaminase / antagonists & inhibitors*
Anoxia / drug therapy*
Enzyme Inhibitors / therapeutic use*
Mice, Knockout
Reg. No./Substance:
0/Enzyme Inhibitors; EC Deaminase

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