| Protection of mouse heart against hypoxic damage by AMP deaminase inhibition. | |
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MedLine Citation:
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PMID: 20544535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical observation in patients with heart disease indicates that reduced activity of AMP deaminase could be protective in heart failure and ischemic heart disease. This study evaluated the effect of 3-[2-(3-carboxy-4-bromo-5,6,7,8-tetrahydronaphthyl)ethyl]-3,6,7,8-tetrahydroimidazo [4,5-d][1,3]diazepin-8-ol, an AMP deaminase inhibitor (AMPDI) in the mouse heart subjected to hypoxia. ApoE/LDLR knock-out mice were subjected to reduced oxygen tension in breathing air. AMPDI was infused before hypoxia in the treated group. We observed amelioration of elcetrocardiographic changes during hypoxia in the treated group that are consistent with a protective effect. |
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Authors:
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T Borkowski; E M Slominska; C Orlewska; S Chlopicki; P Siondalski; M H Yacoub; R T Smolenski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nucleosides, nucleotides & nucleic acids Volume: 29 ISSN: 1532-2335 ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892832 Medline TA: Nucleosides Nucleotides Nucleic Acids Country: England |
Other Details:
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Languages: eng Pagination: 449-52 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Medical University of Gdansk, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AMP Deaminase
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antagonists & inhibitors* Animals Anoxia / drug therapy* Enzyme Inhibitors / therapeutic use* Mice Mice, Knockout |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; EC 3.5.4.6/AMP Deaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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