Document Detail

Protection of Mice from Oral Candidiasis by Heat-killed Enterococcus faecalis, possibly through its Direct Binding to Candida albicans.
MedLine Citation:
PMID:  24682096     Owner:  NLM     Status:  In-Data-Review    
To develop a new therapy against oral candidiasis, a commensal microorganism, Enterococcus faecalis was tested for its ability to modulate Candida growth in vitro and its therapeutic activities against a murine model in vivo. Addition of heat-killed E. faecalis strain EF2001 (EF2001) isolated from healthy human feces to the culture of C. albicans strain TIMM1768 inhibited adherence of the latter to a microtiter plate in a dose dependent manner and Candida cells surrounded by EF2001 were increased. To examine the protective activities of EF2001 in vivo, heat-killed EF2001 was applied orally before and after inoculation of Candida to the tongue of mice previously immunosuppressed. Two days after inoculation this inoculation, both the symptom score and CFU from swabbed-tongue were significantly reduced in the EF2001-treated animals. Histological analysis indicated that EF2001 may potentiate the accumulation of polymorphnuclear cells near a Candida-infected region. These results suggest that oral administration of EF2001 has protective activity against oral candidiasis and that the in vivo activity may be reflected by direct interaction between EF2001 and Candida cells in vitro and the potentiation of an immunostimulatory effect of EF2001.
Sanae A Ishijima; Kazumi Hayama; Kentaro Ninomiya; Masahiro Iwasa; Masatoshi Yamazaki; Shigeru Abe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical mycology journal     Volume:  55     ISSN:  1882-0476     ISO Abbreviation:  Med Mycol J     Publication Date:  2014  
Date Detail:
Created Date:  2014-03-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101562838     Medline TA:  Med Mycol J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  E9-E19     Citation Subset:  IM    
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