Document Detail

Protection Against L-NAME Induced Reduction in Cardiac Output Persists Even After Cessation of Angiotensin Converting Enzyme Inhibitor Treatment.
MedLine Citation:
PMID:  22834875     Owner:  NLM     Status:  Publisher    
AIM: We have demonstrated that short-term angiotensin converting enzyme (ACE) inhibition in adult spontaneously hypertensive rats produces cardiac changes that persist following cessation of treatment that result in a reduced inflammatory, proliferative and fibrotic response to the nitric oxide synthase inhibitor N(ω) -Nitro-L-arginine methyl ester (L-NAME). The present study examines whether prior ACE inhibition with enalapril also protects against L-NAME-induced cardiac dysfunction. METHODS: Rats were treated with enalapril (Enal+L) or tap water (Con, Con+L) for 2 weeks followed by a 2-week washout period. At this point, Con+L and Enal+L rats were treated with L-NAME for 10 days. Hearts were perfused in the working mode, mean arterial pressure (MAP) was assessed via radiotelemetry, and myocardial injury was evaluated in hematoxylin & eosin stained sections. RESULTS: L-NAME increased MAP by a similar magnitude in Con+L and Enal+L. L-NAME induced statistically significant decreases in flow-mediated functional parameters in Con+L rats including cardiac output, stroke volume, and coronary flow. This was prevented by prior enalapril treatment. Prior enalapril did not prevent L-NAME-induced myocardial injury, but may have lessened the degree of it. Regardless of treatment, changes in cardiac function did not correlate with myocardial injury. CONCLUSION: Despite equivalent impact on MAP and incidence of myocardial infarction, prior enalapril treatment resulted in preservation of cardiac function following L-NAME. Understanding the mechanisms by which transient ACE inhibition protects against reductions in cardiac function in the absence of ongoing treatment may reveal novel targets for heart failure treatment. © 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society.
Lauren A Biwer; Tom L Broderick; Haodong Xu; Chad Carroll; Taben M Hale
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-27
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  -     ISSN:  1748-1716     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society.
Department of Basic Medical Sciences, University of Arizona, College of Medicine - Phoenix, Phoenix, AZ.
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