| Protection Against L-NAME Induced Reduction in Cardiac Output Persists Even After Cessation of Angiotensin Converting Enzyme Inhibitor Treatment. | |
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MedLine Citation:
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PMID: 22834875 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: We have demonstrated that short-term angiotensin converting enzyme (ACE) inhibition in adult spontaneously hypertensive rats produces cardiac changes that persist following cessation of treatment that result in a reduced inflammatory, proliferative and fibrotic response to the nitric oxide synthase inhibitor N(ω) -Nitro-L-arginine methyl ester (L-NAME). The present study examines whether prior ACE inhibition with enalapril also protects against L-NAME-induced cardiac dysfunction. METHODS: Rats were treated with enalapril (Enal+L) or tap water (Con, Con+L) for 2 weeks followed by a 2-week washout period. At this point, Con+L and Enal+L rats were treated with L-NAME for 10 days. Hearts were perfused in the working mode, mean arterial pressure (MAP) was assessed via radiotelemetry, and myocardial injury was evaluated in hematoxylin & eosin stained sections. RESULTS: L-NAME increased MAP by a similar magnitude in Con+L and Enal+L. L-NAME induced statistically significant decreases in flow-mediated functional parameters in Con+L rats including cardiac output, stroke volume, and coronary flow. This was prevented by prior enalapril treatment. Prior enalapril did not prevent L-NAME-induced myocardial injury, but may have lessened the degree of it. Regardless of treatment, changes in cardiac function did not correlate with myocardial injury. CONCLUSION: Despite equivalent impact on MAP and incidence of myocardial infarction, prior enalapril treatment resulted in preservation of cardiac function following L-NAME. Understanding the mechanisms by which transient ACE inhibition protects against reductions in cardiac function in the absence of ongoing treatment may reveal novel targets for heart failure treatment. © 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society. |
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Authors:
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Lauren A Biwer; Tom L Broderick; Haodong Xu; Chad Carroll; Taben M Hale |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-27 |
Journal Detail:
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Title: Acta physiologica (Oxford, England) Volume: - ISSN: 1748-1716 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262545 Medline TA: Acta Physiol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society. |
Affiliation:
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Department of Basic Medical Sciences, University of Arizona, College of Medicine - Phoenix, Phoenix, AZ. |
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