| Protecting effect of vitamin E supplementation on submaximal exercise-induced oxidative stress in sedentary dogs as assessed by erythrocyte membrane fluidity and paraoxonase-1 activity. | |
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MedLine Citation:
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PMID: 18479950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this placebo-controlled study was to investigate the effects of oral vitamin E supplementation for 10 weeks on exercise-induced oxidative damage in untrained dogs. Eight dogs were randomly assigned to a supplementation (n=4) or control (n=4) group and underwent two isolated submaximal exercise sessions, 10 weeks apart. Blood was collected during each session to measure erythrocyte membrane fluidity (EMF), paraoxonase-1 (PON1) activity, plasma malondialdehyde (MDA) and vitamin E concentrations. These biomarkers were measured in venous blood samples collected before (t(0)), just after (t, EMF only) and 1d (t+1d) and 7d (t+7d) after the dogs ran on a treadmill. Prior to vitamin E supplementation, exercise induced a significant decrease in PON1 activity, EMF, vitamin E concentration and a significant increase in MDA concentration at t+1d. After a 10 week vitamin E supplementation period, these exercise-induced changes in PON1 activity, EMF and MDA concentration were still significant in the control group, but not in the supplemented group. These results suggested that vitamin E supplementation had a protective effect on submaximal exercise-induced oxidative damage in sedentary dogs. |
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Authors:
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S Motta; C Letellier; M Ropert; C Motta; J J Thiébault |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-13 |
Journal Detail:
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Title: Veterinary journal (London, England : 1997) Volume: 181 ISSN: 1090-0233 ISO Abbreviation: Vet. J. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-07-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706281 Medline TA: Vet J Country: England |
Other Details:
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Languages: eng Pagination: 288-95 Citation Subset: IM |
Affiliation:
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Physiology and Therapeutic Department, National Veterinary School of Lyon, 1, Avenue Bourgelat, 69280 Marcy l'Etoile, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aryldialkylphosphatase / metabolism* Biological Markers Creatine Kinase / metabolism Dietary Supplements Dogs Erythrocyte Membrane / physiology* Male Malondialdehyde / metabolism Oxidative Stress Physical Conditioning, Animal Vitamin E / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 1406-18-4/Vitamin E; 542-78-9/Malondialdehyde; EC 2.7.3.2/Creatine Kinase; EC 3.1.8.1/Aryldialkylphosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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