Document Detail


Protecting effect of vitamin E supplementation on submaximal exercise-induced oxidative stress in sedentary dogs as assessed by erythrocyte membrane fluidity and paraoxonase-1 activity.
MedLine Citation:
PMID:  18479950     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this placebo-controlled study was to investigate the effects of oral vitamin E supplementation for 10 weeks on exercise-induced oxidative damage in untrained dogs. Eight dogs were randomly assigned to a supplementation (n=4) or control (n=4) group and underwent two isolated submaximal exercise sessions, 10 weeks apart. Blood was collected during each session to measure erythrocyte membrane fluidity (EMF), paraoxonase-1 (PON1) activity, plasma malondialdehyde (MDA) and vitamin E concentrations. These biomarkers were measured in venous blood samples collected before (t(0)), just after (t, EMF only) and 1d (t+1d) and 7d (t+7d) after the dogs ran on a treadmill. Prior to vitamin E supplementation, exercise induced a significant decrease in PON1 activity, EMF, vitamin E concentration and a significant increase in MDA concentration at t+1d. After a 10 week vitamin E supplementation period, these exercise-induced changes in PON1 activity, EMF and MDA concentration were still significant in the control group, but not in the supplemented group. These results suggested that vitamin E supplementation had a protective effect on submaximal exercise-induced oxidative damage in sedentary dogs.
Authors:
S Motta; C Letellier; M Ropert; C Motta; J J Thiébault
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-13
Journal Detail:
Title:  Veterinary journal (London, England : 1997)     Volume:  181     ISSN:  1090-0233     ISO Abbreviation:  Vet. J.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706281     Medline TA:  Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  288-95     Citation Subset:  IM    
Affiliation:
Physiology and Therapeutic Department, National Veterinary School of Lyon, 1, Avenue Bourgelat, 69280 Marcy l'Etoile, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aryldialkylphosphatase / metabolism*
Biological Markers
Creatine Kinase / metabolism
Dietary Supplements
Dogs
Erythrocyte Membrane / physiology*
Male
Malondialdehyde / metabolism
Oxidative Stress
Physical Conditioning, Animal
Vitamin E / pharmacology*
Chemical
Reg. No./Substance:
0/Biological Markers; 1406-18-4/Vitamin E; 542-78-9/Malondialdehyde; EC 2.7.3.2/Creatine Kinase; EC 3.1.8.1/Aryldialkylphosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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