Document Detail

Protecting the cochlea during stapes surgery: is there a role for corticosteroids?
MedLine Citation:
PMID:  17245062     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to evaluate possible protective effects of corticosteroids on the inner ear after surgical trauma and to exclude any ototoxicity. A corticosteroid (triamcinolone, Volon A) was topically applied to the inner ear of guinea pigs, either by extracochlear application with permeation and diffusion through the round window membrane or by intracochlear application with direct infusion into the inner ear via a cochleostomy. Threshold and input/output functions of compound action potentials (CAPs) were determined before and after application of the corticosteroid. We found that extracochlear application of the corticosteroid induced insignificant mild shifts of mean CAP thresholds, but significantly increased mean maximal amplitudes of input/output function after the 14th day following application of the steroid. No detrimental effects on cochlear function were noted in the extracochlear group, indicating absence of ototoxicity with the concentrations used. In the intracochlear group, CAP thresholds and amplitudes of input/ output function recovered from partial hearing loss due to cochleostomy between 7 and 14 days after application of the steroid, whereas in controls without steroid application, no such recovery of hearing was detected. These results suggest that topical application of triamcinolone has no ototoxic effect and that it leads to increased recovery of cochlear functions after trauma in the guinea pig inner ear.
Jan Kiefer; Qing Ye; Jochen Tillein; O Adunka; Wolfgang Arnold; Wolfgang Gstöttner
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in oto-rhino-laryngology     Volume:  65     ISSN:  0065-3071     ISO Abbreviation:  Adv. Otorhinolaryngol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-01-24     Completed Date:  2007-04-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0242534     Medline TA:  Adv Otorhinolaryngol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  300-7     Citation Subset:  IM    
Klinik für Hals-Nasen-Ohrenheilkunde, Klinikum rechts der Isar, Technische niversität München, Munich, Germany.
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MeSH Terms
Administration, Topical
Anti-Inflammatory Agents / administration & dosage*,  toxicity
Auditory Threshold / drug effects
Cochlea / drug effects*,  surgery
Cochlear Nerve / drug effects
Evoked Potentials, Auditory / drug effects
Guinea Pigs
Postoperative Complications / prevention & control*
Round Window, Ear / drug effects
Stapes Surgery / methods*
Triamcinolone Acetonide / administration & dosage*,  toxicity
Wound Healing / physiology
Reg. No./Substance:
0/Anti-Inflammatory Agents; 76-25-5/Triamcinolone Acetonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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