| Proteasomal recognition of ubiquitylated substrates. | |
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MedLine Citation:
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PMID: 20399133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ubiquitin/26S proteasome-mediated proteolysis controls the half-life of numerous critical regulatory proteins and is an intimate regulatory component for nearly all aspects of cellular processes. In addition to ubiquitin conjugation, an additional level of substrate specificity is regulated at the step of proteasomal recognition of ubiquitylated substrates, which serves as an important mechanistic and regulatory component to connect the substrate from the conjugation machinery to the 26S proteasome. In this review, we discuss current knowledge and future challenges relevant to understanding the mechanism, regulation, functions and substrate specificity of proteasomal recognition mediated by a multitude of ubiquitin receptors. The mechanistic details of major recognition pathways for ubiquitylated substrates are clearly divergent within and across species, which implies functional differentiation. |
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Authors:
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Hongyong Fu; Ya-Ling Lin; A S Fatimababy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-04-14 |
Journal Detail:
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Title: Trends in plant science Volume: 15 ISSN: 1878-4372 ISO Abbreviation: Trends Plant Sci. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-05 Completed Date: 2010-09-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9890299 Medline TA: Trends Plant Sci Country: England |
Other Details:
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Languages: eng Pagination: 375-86 Citation Subset: IM |
Affiliation:
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Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan 115, ROC. hongyong@gate.sinica.edu.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Proteasome Endopeptidase Complex / metabolism* Protein Binding Signal Transduction Substrate Specificity Ubiquitination* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.25.1/Proteasome Endopeptidase Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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