| Proteases implicated in apoptosis: old and new. | |
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MedLine Citation:
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PMID: 20609057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The role of proteases in the regulation of apoptosis is becoming increasingly apparent. Whilst many of these proteases are already characterised, some have yet to be identified. Traditionally caspases held the traditional role as the prime mediators of apoptosis; however, attention is now turning towards the contribution made by serine proteases. KEY FINDINGS: As unregulated apoptosis is implicated in various disease states, the emergence of this proteolytic family as apoptotic regulators offers novel and alterative opportunities for therapeutic targets. SUMMARY: This review presents a brief introduction and overview of proteases in general with particular attention given to those involved in apoptotic processing. |
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Authors:
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Kelly L Moffitt; S Lorraine Martin; Brian Walker |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 62 ISSN: 2042-7158 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2011-01-31 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 563-76 Citation Subset: IM |
Affiliation:
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Biomolecular Sciences Group, School of Pharmacy, Queen's University of Belfast, Belfast BT97BL, Northern Ireland, UK. k.moffitt@qub.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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physiology* Humans Peptide Hydrolases / metabolism* Serine Proteases / metabolism |
| Chemical | |
Reg. No./Substance:
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EC 3.4.-/Peptide Hydrolases; EC 3.4.-/Serine Proteases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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