Document Detail


Proteases implicated in apoptosis: old and new.
MedLine Citation:
PMID:  20609057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The role of proteases in the regulation of apoptosis is becoming increasingly apparent. Whilst many of these proteases are already characterised, some have yet to be identified. Traditionally caspases held the traditional role as the prime mediators of apoptosis; however, attention is now turning towards the contribution made by serine proteases.
KEY FINDINGS: As unregulated apoptosis is implicated in various disease states, the emergence of this proteolytic family as apoptotic regulators offers novel and alterative opportunities for therapeutic targets.
SUMMARY: This review presents a brief introduction and overview of proteases in general with particular attention given to those involved in apoptotic processing.
Authors:
Kelly L Moffitt; S Lorraine Martin; Brian Walker
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  62     ISSN:  2042-7158     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2011-01-31     Revised Date:  2011-09-13    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  563-76     Citation Subset:  IM    
Affiliation:
Biomolecular Sciences Group, School of Pharmacy, Queen's University of Belfast, Belfast BT97BL, Northern Ireland, UK. k.moffitt@qub.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / physiology*
Humans
Peptide Hydrolases / metabolism*
Serine Proteases / metabolism
Chemical
Reg. No./Substance:
EC 3.4.-/Peptide Hydrolases; EC 3.4.-/Serine Proteases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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