| Protease-antiprotease imbalance, hemodynamic and regional blood flow changes in experimental pancreatitis. | |
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MedLine Citation:
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PMID: 3551052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pathologic proteolysis in pancreatitis is an important clue to understand the pathophysiology in pancreatitis. Impairment of pancreatic circulation is also important in the development of severe pancreatitis. In an attempt to study some of the biochemical and circulatory events in experimental pancreatitis in the pig the following experiments were undertaken. Pancreatic and splanchnic blood flow were studied in severe and mild pancreatitis with the microsphere method, together with cardiac output and mean arterial pressure. Kininogen, alpha-2-macroglobulin and alpha-1-proteinase inhibitor were measured in plasma and in peritoneal fluid. In severe pancreatitis consumption of kininogen in the peritoneal cavity was demonstrated together with a final lowering of the plasma protease inhibitors. This was accompanied by a rapid reduction of cardiac output and finally mean arterial blood pressure. Pancreatic blood flow was profoundly diminished in this group. No such changes were found in mild pancreatitis. It is concluded that pancreatic ischemia in pancreatitis is associated with protease-antiprotease imbalance. |
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Authors:
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B Hjelmqvist; K Ohlsson; K F Aronsen |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of gastroenterology. Supplement Volume: 126 ISSN: 0085-5928 ISO Abbreviation: Scand. J. Gastroenterol. Suppl. Publication Date: 1986 |
Date Detail:
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Created Date: 1987-05-08 Completed Date: 1987-05-08 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0437034 Medline TA: Scand J Gastroenterol Suppl Country: NORWAY |
Other Details:
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Languages: eng Pagination: 8-11 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Hemodynamics Ischemia / physiopathology Pancreas / blood supply* Pancreatitis / physiopathology* Peptide Hydrolases / metabolism* Protease Inhibitors / metabolism* Regional Blood Flow Splanchnic Circulation Swine |
| Chemical | |
Reg. No./Substance:
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0/Protease Inhibitors; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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