Document Detail

Protean infectious types and frequent association with neurosurgical procedures in adult Serratia marcescens CNS infections: report of two cases and review of the literature.
MedLine Citation:
PMID:  11532558     Owner:  NLM     Status:  MEDLINE    
Serratia marcescens is a rare pathogen of adult central nervous system (CNS) infection. We report on the clinical features and therapeutic outcomes of two adult patients with such infections. The clinical characteristics of 13 other reported adult cases are also included for analysis. The 15 cases were nine males and six females, aged 19-83 years, in whom, underlying post-neurosurgical states and ear operation were noted in 93% (14/15). Fever and conscious disturbance were the most common clinical manifestations of these 15 cases, followed by hydrocephalus, seizures, and wound infections. The manifestation types were protean, including meningitis and focal suppurations such as brain abscess, cranial and spinal epidural abscess, cranial subdural abscess, and infected lumbar pseudomeningocele. One case of S. marcescens CNS infection was diagnosed postmortem; the other 14 were diagnosed by the positive culture from CSF or pus. Antibiotic therapy with or without neurosurgical intervention was the management strategy in 14/15 cases. The therapeutic results showed a high mortality rate.
C R Huang; C H Lu; C C Chien; W N Chang
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  103     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-09-04     Completed Date:  2001-12-04     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  171-4     Citation Subset:  IM    
Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung, 123, Ta Pei Road, Niao Sung Hsiang, Hsien, Kaohsiung, Taiwan, ROC.
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MeSH Terms
Aged, 80 and over
Central Nervous System Infections / etiology*,  mortality*,  therapy
Middle Aged
Neurosurgical Procedures / adverse effects*
Proteus Infections / etiology*,  mortality*,  therapy
Serratia Infections / etiology*,  mortality*,  therapy
Serratia marcescens / isolation & purification*
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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