Document Detail

Protamines. III. Synthesis of the tetradecapeptide corresponding to the C-terminal sequence 52--65 of galline.
MedLine Citation:
PMID:  489253     Owner:  NLM     Status:  MEDLINE    
The synthesis of peptides containing blocks of arginyl residues is proposed through amidination of the corresponding ornithyl analogs. In order to test this strategy the ornithyl analog of the C-terminal sequence 52--65 of galline was synthesized by the conventional method. The amidination reaction, performed on fragments of different length and ornithyl-residue content, quantitatively converts ornithines into arginines. The strategy proposed may represent a powerful tool for the synthesis of protamines and other basic proteins.
F Marchiori; G Borin; B Filippi; V Moretto; G M Bonora; C Toniolo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of peptide and protein research     Volume:  14     ISSN:  0367-8377     ISO Abbreviation:  Int. J. Pept. Protein Res.     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0330420     Medline TA:  Int J Pept Protein Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  143-52     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Amino Acids / analysis
Peptide Fragments
Peptides / analysis,  chemical synthesis*
Protamines / analysis,  chemical synthesis*
Reg. No./Substance:
0/Amidines; 0/Amino Acids; 0/Peptide Fragments; 0/Peptides; 0/Protamines

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