| Protamine inhibits coronary collateral development in a canine model of repetitive coronary occlusion. | |
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MedLine Citation:
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PMID: 7532374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Protamine has been demonstrated to inhibit angiogenesis in vitro and in vivo; however, its effect on coronary collateral development has not been examined. The present investigation tested the hypothesis that subcutaneously administered protamine inhibits canine coronary collateral development in response to chronic myocardial ischemia. Dogs underwent daily, repetitive, 2-min, left anterior descending coronary artery (LAD) occlusions for 22 consecutive days. Regional myocardial blood flow (radioactive microspheres), LAD segment shortening, and coronary flow debt repayment were measured in saline-treated (n = 7) and protamine-treated (n = 6) dogs on days 1, 8, 15, and 22. Coronary collateral development in saline-treated dogs was demonstrated by time-dependent significant (P < 0.05) increases in collateral blood flow to ischemic myocardium [day 1 0.10 +/- 0.01 vs. day 22 0.88 +/- 0.05 (SE) ml.min-1.g-1], progressive normalization of myocardial contractile function during LAD occlusion, and successive reduction in flow debt repayment. In contrast, protamine treatment significantly attenuated, increases in collateral perfusion (day 1 0.13 +/- 0.02 vs. day 22 0.36 +/- 0.03 ml.min-1.g-1). Regional contractile dysfunction and postocclusive reactive hyperemic responses were sustained over time in protamine-treated compared with saline-treated dogs. The results demonstrate that protamine inhibits coronary collateral development in response to chronic myocardial ischemia. |
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Authors:
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J R Kersten; P S Pagel; D C Warltier |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 268 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-03-20 Completed Date: 1995-03-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H720-8 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Collateral Circulation / drug effects* Coronary Circulation / drug effects* Coronary Disease / physiopathology* Dogs Hemodynamics / drug effects Hyperemia / physiopathology Myocardial Contraction / drug effects Neovascularization, Pathologic / prevention & control* Protamines / pharmacology* Recurrence |
| Grant Support | |
ID/Acronym/Agency:
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GM-08377/GM/NIGMS NIH HHS; HL-36144/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Protamines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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