| Prosthetic vascular graft infection: the role of 18F-FDG PET/CT. | |
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MedLine Citation:
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PMID: 17631553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Graft infection after prosthetic vascular reconstruction is an uncommon but severe complication. The clinical presentation is often subtle and nonspecific and may occur long after surgery. Although defining a prosthetic vascular graft infection can be difficult, early diagnosis and treatment are important because of the relatively high rates of amputation and death. The present study assessed the role of PET/CT using 18F-FDG for the diagnosis of vascular graft infections. METHODS: Thirty-nine patients (35 men and 4 women; age range, 44-82 y) with suspected vascular graft infection underwent 18F-FDG PET/CT. The performance of PET/CT for the diagnosis of an infectious process and its localization to the graft or soft tissues was assessed. The final diagnosis was based on histopathologic findings and microbiologic assays obtained at surgery or on clinical and imaging follow-up. RESULTS: PET/CT detected foci of increased 18F-FDG uptake suspected as infection in 27 patients and localized these findings to the graft in 16 patients. Vascular graft infection was confirmed in 14 of these patients (88%). PET/CT excluded graft involvement in 11 patients, and in 10 (91%) of these 11, long-term follow-up further confirmed that the infectious process was limited to surrounding soft tissues only. No abnormal 18F-FDG uptake was found in any of the 12 patients with no further evidence of infection. PET/CT had a sensitivity of 93%, specificity of 91%, positive predictive value of 88%, and negative predictive value of 96% for the diagnosis of vascular graft infection. CONCLUSION: 18F-FDG PET/CT is a reliable noninvasive imaging modality for the diagnosis of vascular graft-related infection. The precise anatomic localization of increased 18F-FDG uptake provided by PET/CT enables accurate differentiation between graft and soft-tissue infection. |
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Authors:
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Zohar Keidar; Ahuva Engel; Aaron Hoffman; Ora Israel; Samy Nitecki |
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Publication Detail:
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Type: Journal Article Date: 2007-07-13 |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 48 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-03 Completed Date: 2007-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1230-6 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel. zohar@keidar.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Blood Vessel Prosthesis Implantation / adverse effects* Female Fluorodeoxyglucose F18 / diagnostic use* Humans Male Middle Aged Positron-Emission Tomography / methods* Prosthesis-Related Infections / diagnosis* Radiopharmaceuticals / diagnostic use* Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
Comment In:
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J Nucl Med. 2007 Aug;48(8):1227-9
[PMID:
17673424
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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