Document Detail

Prosthetic valve sewing-ring sealing with antibiotic and fibrin glue in infective endocarditis. A prospective clinical study.
MedLine Citation:
PMID:  17669758     Owner:  NLM     Status:  MEDLINE    
To analyze the benefits of prosthetic valve sewing ring sealing with antibiotic and fibrin glue in endocarditis, a prospective study was undertaken in 16 consecutive patients. Valvular lesions concerned aortic valve in seven patients, mitral valve in three and both in six. Preoperative antibiotic treatment was started 15+/-15 days before surgery. Peroperative findings showed six isolated valvular lesions and ten perivalvular extensions. Before the prostheses were sutured to the annulus, the Dacron sewing rings were covered with antibiotic and fibrin glue. The antibiotic was chosen according to the micro-organism identified preoperatively. We didn't have any peroperative mortality or paravalvular leakage (PVL). One patient died suddenly on postoperative day (POD) nine (non-contributive autopsy). Another patient was reoperated on POD 31 for PVL. Peroperative local bacteriological examinations were sterile. Mean follow-up was of 9.3+/-6.8 months and was completed in all cases. Actuarial survival rate was 94+/-6% and freedom from reoperation was 92+/-7%. Antibiotic treatment was stopped after 59+/-64 days for 10 patients. None of them had recurrence of endocarditis or PVL. Prosthetic valve sewing ring sealing with adapted antibiotic and fibrin glue can constitute a good weapon in the armamentarium of surgical treatment of active endocarditis.
Fadi Farhat; Marion Durand; François Delahaye; Olivier Jegaden
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Publication Detail:
Type:  Journal Article     Date:  2006-11-24
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  6     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-08-02     Completed Date:  2007-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  16-20     Citation Subset:  IM    
Department of Cardiovascular Surgery B, Claude Bernard University, INSERM E226, Louis Pradel Hospital, Bron Cedex, France.
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MeSH Terms
Anti-Infective Agents / administration & dosage*
Endocarditis, Bacterial / surgery*
Fibrin Tissue Adhesive / administration & dosage*
Heart Valve Prosthesis*
Heart Valve Prosthesis Implantation*
Middle Aged
Postoperative Complications / surgery*
Prospective Studies
Prosthesis-Related Infections / surgery*
Survival Rate
Suture Techniques
Treatment Outcome
Reg. No./Substance:
0/Anti-Infective Agents; 0/Fibrin Tissue Adhesive

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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