Document Detail

Prosthetic valve endocarditis due to Listeria monocytogenes. Report of two cases and reviews.
MedLine Citation:
PMID:  14732327     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Endocarditis due to Listeria monocytogenes is a rare but serious disease often leading to valve dysfunction and heart failure. Two cases of listerial prosthetic valve endocarditis are reviewed along with 66 cases previously reported. RESULTS: The mean age of patients with listerial endocarditis increased from 47.1 years in the decades from 1955-1984 to 65.5 years from 1985-2000. Chronic debilitating diseases, solid tumours and immunosuppression associated with organ transplantation, hematologic neoplasia or AIDS were found in 41.1% of cases. Listerial endocarditis was a vegetative and destructive process, with dehiscense of the prosthesis and occasionally, abscess formation, fistulization and pericarditis. Treatment with penicillin or ampicillin alone or combined with gentamicin was adequate therapy in most cases. Vancomycin together with gentamicin may be a reasonable alternative therapy. CONCLUSIONS: Despite problems associated with microbial persistence and relapses in other forms of human listeriosis, antimicrobial therapy alone may be a successful treatment for listerial endocarditis, including cases occurring on prosthetic valves. Valve replacement may be reserved for complicated cases with valve dehiscense, cardiac failure or myocardial abscess. Overall mortality was 35.3%, although most patients who died did so before 1985 and since then mortality has been significantly reduced to 12%.
Manuel L Fernández Guerrero; Pablo Rivas; Rosa Rábago; Antonio Núñez; Miguel de Górgolas; Jorge Martinell
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases     Volume:  8     ISSN:  1201-9712     ISO Abbreviation:  Int. J. Infect. Dis.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-01-20     Completed Date:  2004-04-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9610933     Medline TA:  Int J Infect Dis     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  IM    
División of Infectious Diseases, Cardiology and Department of Cardiac Surgery, Fundación Jiménez Di;az, Universidad Autónoma de Madrid, Spain.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Endocarditis, Bacterial / complications,  drug therapy,  microbiology*
Follow-Up Studies
Heart Failure / etiology
Heart Valve Diseases / etiology
Heart Valve Prosthesis / adverse effects*,  microbiology
Listeria Infections / complications,  drug therapy,  microbiology*
Listeria monocytogenes / pathogenicity*
Prosthesis-Related Infections / complications,  drug therapy,  microbiology*
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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