Document Detail


Prostatic arterial embolization to treat benign prostatic hyperplasia.
MedLine Citation:
PMID:  21195898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate whether prostatic arterial embolization (PAE) might be a feasible procedure to treat lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH).
MATERIALS AND METHODS: Fifteen patients (age range, 62-82 years; mean age, 74.1 y) with symptomatic BPH after failure of medical treatment were selected for PAE with nonspherical 200-μm polyvinyl alcohol particles. The procedure was performed by a single femoral approach. Technical success was considered when selective prostatic arterial catheterization and embolization was achieved on at least one pelvic side.
RESULTS: PAE was technically successful in 14 of the 15 patients (93.3%). There was a mean follow-up of 7.9 months (range, 3-12 months). International Prostate Symptom Score decreased a mean of 6.5 points (P = .005), quality of life improved 1.14 points (P = .065), International Index of Erectile Function increased 1.7 points (P = .063), and peak urinary flow increased 3.85 mL/sec (P = .015). There was a mean prostate-specific antigen reduction of 2.27 ng/mL (P = .072) and a mean prostate volume decrease of 26.5 mL (P = .0001) by ultrasound and 28.9 mL (P = .008) by magnetic resonance imaging. There was one major complication (a 1.5-cm(2) ischemic area of the bladder wall) and four clinical failures (28.6%).
CONCLUSIONS: In this small group of patients, PAE was a feasible procedure, with preliminary results and short-term follow-up suggesting good symptom control without sexual dysfunction in suitable candidates, associated with a reduction in prostate volume.
Authors:
João M Pisco; Luis C Pinheiro; Tiago Bilhim; Marisa Duarte; Jorge R Mendes; Antonio G Oliveira
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of vascular and interventional radiology : JVIR     Volume:  22     ISSN:  1535-7732     ISO Abbreviation:  J Vasc Interv Radiol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-04-18     Revised Date:  2012-01-19    
Medline Journal Info:
Nlm Unique ID:  9203369     Medline TA:  J Vasc Interv Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11-9; quiz 20     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 SIR. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Radiology, Faculty of Medical Sciences, New University of Lisbon, Lisbon, Portugal. joao.pisco@chln.min-saude.pt
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Arteries
Biopsy
Embolization, Therapeutic* / adverse effects
Feasibility Studies
Humans
Ischemia / etiology
Magnetic Resonance Imaging
Male
Middle Aged
Organ Size
Penile Erection
Pilot Projects
Polyvinyl Alcohol / administration & dosage*,  adverse effects
Portugal
Prospective Studies
Prostate / blood supply*,  pathology,  ultrasonography
Prostate-Specific Antigen / blood
Prostatic Hyperplasia / diagnosis,  physiopathology,  psychology,  therapy*
Quality of Life
Recovery of Function
Time Factors
Treatment Outcome
Urinary Bladder / blood supply
Urodynamics
Chemical
Reg. No./Substance:
9002-89-5/Polyvinyl Alcohol; EC 3.4.21.77/Prostate-Specific Antigen
Comments/Corrections
Comment In:
J Urol. 2012 Jan;187(1):212-3   [PMID:  22153448 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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