| Prostatic acid phosphatase, a neglected ectonucleotidase. | |
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MedLine Citation:
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PMID: 19322680 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Two recent papers reveal that the soluble and secreted prostatic acid phosphatase, an enzyme that has long served as a diagnostic marker for prostate cancer, has a membrane-bound splice variant. This enzyme exhibits ecto-5'-nucleotidase activity, is widely distributed, and implicated in the formation of chronic pain. While prostatic acid phosphatase hydrolyzes phosphomonoesters other than 5'-nucleoside monophosphates these novel data suggest that, in addition to ecto-5'-nucleotidase and the alkaline phosphatases, prostatic acid phosphatase must be taken into account in future studies on extracellular adenosine production. |
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Authors:
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Herbert Zimmermann |
Publication Detail:
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Type: Journal Article Date: 2009-03-26 |
Journal Detail:
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Title: Purinergic signalling Volume: 5 ISSN: 1573-9538 ISO Abbreviation: Purinergic Signal. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-07-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101250499 Medline TA: Purinergic Signal Country: Netherlands |
Other Details:
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Languages: eng Pagination: 273-5 Citation Subset: - |
Affiliation:
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Institute of Cell Biology and Neuroscience, Biocenter, Goethe-University, 60438, Frankfurt, Germany, h.zimmermann@bio.uni-frankurt.de. |
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