Document Detail

Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers.
MedLine Citation:
PMID:  19716160     Owner:  NLM     Status:  MEDLINE    
Prostate-specific membrane antigen (PSMA), a type II transmembrane metallo-peptidase highly overexpressed in prostate cancer cells, has been studied as a targeting molecule in prostate cancer. Recently, PSMA has also been found to be expressed in the neovasculature of multiple nonprostatic solid tumors. Because of its unique expression pattern limited to tumor-associated endothelial cells, PSMA may also be an interesting molecule for vascular targeting. In this study, PSMA expression was determined by immunohistochemistry in 119 cases of primary gastric adenocarcinoma, 130 cases of primary colorectal adenocarcinoma, and 24 metastasis of colorectal adenocarcinoma. Expression data were correlated with clinicopathologic information. PSMA expression was detected in tumor-associated neovasculature of 79 (66%) of 119 gastric and 110 (85%) of 130 colorectal carcinomas. Furthermore, the neovasculatures of 16 (84%) of 19 liver and 4 (80%) of 5 nodal metastases from colorectal carcinomas were prostate-specific membrane antigen positive. There was a trend for high-grade tumors to higher PSMA expression (Spearman r = 0.18, P = .046) in colorectal cancers. No association between PSMA expression and overall- or disease-free survival was observed in gastric or colorectal cancers. This study provides the first in-depth look at PSMA expression in gastric and colorectal cancer. Because of its highly tumor-restricted expression and its accessibility to targeted therapy, PSMA represents a promising therapeutic and diagnostic target in colorectal and gastric cancer.
Michael C Haffner; Irmgard E Kronberger; Jeffrey S Ross; Christine E Sheehan; Matthias Zitt; Gilbert Mühlmann; Dietmar Ofner; Bettina Zelger; Christian Ensinger; Ximing J Yang; Stephan Geley; Raimund Margreiter; Neil H Bander
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-27
Journal Detail:
Title:  Human pathology     Volume:  40     ISSN:  1532-8392     ISO Abbreviation:  Hum. Pathol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-16     Completed Date:  2009-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1754-61     Citation Subset:  IM    
Division of Medical Biochemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.
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MeSH Terms
Adenocarcinoma / blood supply,  metabolism*
Aged, 80 and over
Antigens, Surface / biosynthesis*
Colorectal Neoplasms / blood supply,  metabolism*
Fluorescent Antibody Technique
Glutamate Carboxypeptidase II / biosynthesis*
Microscopy, Confocal
Middle Aged
Neoplasm Staging
Neovascularization, Pathologic / metabolism*
Stomach Neoplasms / blood supply,  metabolism*
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Antigens, Surface; 0/Tumor Markers, Biological; EC Carboxypeptidase II; EC carboxypeptidase II, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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