Document Detail


Prostate-specific antigen to ascertain reliability of self-reported coital exposure to semen.
MedLine Citation:
PMID:  16865047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of this study was to assess the validity of women's reports of recent unprotected sex by testing for prostate-specific antigen (PSA) in vaginal samples. STUDY DESIGN: The authors conducted prospective research with 332 female sex workers attending 2 public dispensaries in Madagascar. RESULTS: Among women who reported no sex or protected sex only within the past 48 hours, 21% and 39%, respectively, tested positive for PSA. Among those testing positive for PSA, no differences in PSA concentrations were found among those reporting no sex, protected sex only, or at least one unprotected act. CONCLUSIONS: The substantial disagreement between self-reports and measurement of a biologic marker of semen exposure in vaginal specimens substantiates that self-reports of sexual behavior cannot be assumed to be valid measures. Future sexually transmitted infection/HIV and pregnancy prevention studies should confirm the validity of self-reports or use end points that do not rely on self-reported data.
Authors:
Maria F Gallo; Frieda M Behets; Markus J Steiner; Marcia M Hobbs; Theresa Hatzell Hoke; Kathleen Van Damme; Louisette Ralimamonjy; Leonardine Raharimalala; Myron S Cohen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies    
Journal Detail:
Title:  Sexually transmitted diseases     Volume:  33     ISSN:  0148-5717     ISO Abbreviation:  Sex Transm Dis     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-25     Completed Date:  2006-10-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7705941     Medline TA:  Sex Transm Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  476-9     Citation Subset:  IM    
Affiliation:
Family Health International (FHI), Research Triangle Park, North Carolina, USA. mgallo@cdc.gov
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MeSH Terms
Descriptor/Qualifier:
Coitus*
Condoms / utilization
Data Collection / standards*
Female
Humans
Madagascar / epidemiology
Male
Predictive Value of Tests
Prospective Studies
Prostate-Specific Antigen / metabolism*
Prostitution
Questionnaires
Randomized Controlled Trials as Topic
Reproducibility of Results
Semen / metabolism*
Sexually Transmitted Diseases / epidemiology,  etiology,  prevention & control*
Unsafe Sex / statistics & numerical data*
Vaginal Smears
Grant Support
ID/Acronym/Agency:
N01 AI075329/AI/NIAID NIH HHS; U19 AI031496/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.21.77/Prostate-Specific Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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