Document Detail

Prostate-specific antigen as a marker of bone metastasis in patients with prostate cancer.
MedLine Citation:
PMID:  8860738     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Staging in patients with newly diagnosed untreated cancer of the prostate has significant ramifications on the management of the disease. Currently measurement of the serum prostate-specific antigen (PSA) concentration and radionuclide bone scan are two important procedures in the metastatic workup of these patients. We retrospectively evaluated the efficacy of PSA as a staging marker to discriminate prostate cancer patients with bone metastases from those without bone metastases. MATERIALS AND METHODS: In a retrospective study 158 prostate cancer patients with (n = 21) and without (n = 137) bone metastases were analyzed. In all patients the initial PSA measurement as well as the radionuclide bone scan were evaluated. RESULTS: Patients with bone metastases demonstrated a median serum PSA concentration of 151 ng/ml and only 1 patient revealed a serum PSA concentration of <10 ng/ml. This resulted in a negative predictive value of 98%. In addition 67% of these patients demonstrated a serum PSA concentration of >100 ng/ml, which resulted in a positive predictive value of 74% and an overall accuracy of 92%. CONCLUSION: The serum PSA concentration seems to provide useful information with regard to the presence of bone metastasis in patients with newly diagnosed cancer of the prostate. A serum PSA value of <10 ng/ml nearly excludes bone metastases, whereas a serum PSA value of> 100 ng/ml is highly predictive of bone metastases.
J M Wolff; R Bares; P K Jung; U Buell; G Jakse
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Urologia internationalis     Volume:  56     ISSN:  0042-1138     ISO Abbreviation:  Urol. Int.     Publication Date:  1996  
Date Detail:
Created Date:  1997-02-19     Completed Date:  1997-02-19     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  0417373     Medline TA:  Urol Int     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  IM    
Departments of Urology, Aachen University of Technology, Aachen, Germany.
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MeSH Terms
Aged, 80 and over
Bone Neoplasms / diagnosis*,  radionuclide imaging,  secondary*
Middle Aged
Predictive Value of Tests
Prostate-Specific Antigen / blood*
Prostatic Neoplasms / immunology,  pathology*
ROC Curve
Retrospective Studies
Sensitivity and Specificity
Reg. No./Substance:
EC Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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