| Prostate gland edema after single-fraction high-dose rate brachytherapy before external beam radiation therapy. | |
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MedLine Citation:
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PMID: 20149758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: High-dose rate brachytherapy (HDRB) is frequently used as a boost to external beam radiation therapy (EBRT) in prostate cancer patients. With the increasing use of small planning target volume margins in EBRT, prostatic edema induced by HDRB can be a contributing factor to geometric miss when HDRB is performed before or during EBRT. We assessed prostate gland volumetric change after single-fraction HDRB and its impact on definition of treatment volume for EBRT. METHODS AND MATERIALS: Thirty-one consecutive patients with intermediate-risk prostate cancer treated with single-fraction HDRB (10 Gy) combined with hypofractionated EBRT were analyzed. A second CT scan was performed 7 days after HDRB, and images were coregistered with the planning CT scan that contained the original clinical target volume (CTV). The post-HDRB prostate CTV volume was compared with the original CTV by a single observer. RESULTS: All patients presented volumetric variation. In most cases (68%), the prostate increased in volume, whereas it decreased in 32%. The mean prostatic volume was 42.2 cc before HDRB and 43.6 cc after HDRB, representing a mean volume difference of 3.4%, ranging from -14.2% to 23.8% (p=0.756). This difference is the result of mean changes of 0.6mm (-6.1 to 6.6) in the anterior-posterior, 0.5mm (-5.5 to 3.0) in the lateral, and 0.2mm (-5.0 to 5.0) in the superior-inferior axes. CONCLUSIONS: Although a nonsignificant volumetric change occurs after single-fraction HDRB, individual variations on specific axis could lead to important uncertainties during EBRT. |
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Authors:
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Fabio L Cury; Marie Duclos; Armen Aprikian; Horacio Patrocinio; Luis Souhami |
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Publication Detail:
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Type: Journal Article Date: 2010-02-09 |
Journal Detail:
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Title: Brachytherapy Volume: 9 ISSN: 1873-1449 ISO Abbreviation: Brachytherapy Publication Date: 2010 Jul-Sep |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137600 Medline TA: Brachytherapy Country: United States |
Other Details:
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Languages: eng Pagination: 208-12 Citation Subset: IM |
Copyright Information:
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(c) 2010. Published by Elsevier Inc. |
Affiliation:
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Division of Radiation Oncology, Department of Oncology, McGill University Health Centre, Montreal, Quebec, Canada. fabio.cury@muhc.mcgill.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brachytherapy
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adverse effects* Dose Fractionation Edema / etiology* Humans Male Prostate / radiation effects* Prostatic Neoplasms / complications, radiotherapy* Radiotherapy, Conformal Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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