Document Detail


Prostate cancer susceptibility Loci identified on chromosome 12 in African Americans.
MedLine Citation:
PMID:  21358824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prostate cancer (PCa) is a complex disease that disproportionately affects African Americans and other individuals of African descent. A number of regions across the genome have been associated to PCa, most of them with moderate effects. A few studies have reported chromosomal changes on 12p and 12q that occur during the onset and development of PCa but to date no consistent association of the disease with chromosome 12 polymorphic variation has been identified. In order to unravel genetic risk factors that underlie PCa health disparities we investigated chromosome 12 using ancestry informative markers (AIMs), which allow us to distinguish genomic regions of European or West African origin, and tested them for association with PCa. Additional SNPs were genotyped in those areas where significant signals of association were detected. The strongest signal was discovered at the SNP rs12827748, located upstream of the PAWR gene, a tumor suppressor, which is amply expressed in the prostate. The most frequent allele in Europeans was the risk allele among African Americans. We also examined vitamin D related genes, VDR and CYP27B1, and found a significant association of PCa with the TaqI polymorphism (rs731236) in the former. Although our results warrant further investigation we have uncovered a genetic susceptibility factor for PCa in a likely candidate by means of an approach that takes advantage of the differential contribution of parental groups to an admixed population.
Authors:
Carolina Bonilla; Stanley Hooker; Tshela Mason; Cathryn H Bock; Rick A Kittles
Related Documents :
21176964 - Genotoxicity and mutagenicity of water samples from the monjolinho river (brazil) after...
21536234 - Philadelphia chromosome symposium: commemoration of the 50th anniversary of the discove...
2240034 - Familial sex chromosomal mosaicism.
21504564 - Complex chromosome rearrangements related 15q14 microdeletion plays a relevant role in ...
23819574 - Chromosomal diversification and karyotype evolution of diploids in the cytologically di...
3265304 - Spontaneous chromosomal anomalies in lymphocytes from xeroderma pigmentosum. a study of...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-02-16
Journal Detail:
Title:  PloS one     Volume:  6     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-01     Completed Date:  2011-09-01     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e16044     Citation Subset:  IM    
Affiliation:
School of Social and Community Medicine, University of Bristol, Bristol, Avon, United Kingdom. C.Bonilla@bristol.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Africa, Western / ethnology
African Americans / genetics*
Aged
Apoptosis Regulatory Proteins / genetics
Carcinoma / ethnology,  genetics*
Case-Control Studies
Chromosomes, Human, Pair 12* / genetics
European Continental Ancestry Group / genetics
Genetic Loci*
Genetic Predisposition to Disease / ethnology*,  genetics
Genome-Wide Association Study
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Prostatic Neoplasms / ethnology,  genetics*
Chemical
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/prostate apoptosis response-4 protein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Satellite telemetry and long-range bat movements.
Next Document:  Mio-pliocene faunal exchanges and african biogeography: the record of fossil bovids.