| Prostate cancer: sextant localization with MR imaging, MR spectroscopy, and 11C-choline PET/CT. | |
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MedLine Citation:
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PMID: 17652190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To retrospectively compare sensitivity and specificity of magnetic resonance (MR) imaging, three-dimensional (3D) MR spectroscopy, combined MR imaging and 3D MR spectroscopy, and carbon 11 (11C)-choline positron emission tomography (PET)/computed tomography (CT) for intraprostatic tumor sextant localization, with histologic findings as reference standard. MATERIALS AND METHODS: The local ethics committee on human research provided approval and a waiver of informed consent for the retrospective study. MR imaging, 3D MR spectroscopy, and 11C-choline PET/CT results were retrospectively reviewed in 26 men with biopsy-proved prostate cancer (mean age, 64 years; range, 51-75 years) who underwent radical prostatectomy. Cancer was identified as areas of nodular low signal intensity on T2-weighted MR images. At 3D MR spectroscopy, choline-plus-creatine-to-citrate and choline-to-creatine ratios were used to distinguish healthy from malignant voxels. At PET/CT, focal uptake was visually assessed, and maximum standardized uptake values (SUVs) were recorded. Agreement between 3D MR spectroscopic and PET/CT results was calculated, and ability of maximum SUV to help localize cancer was assessed with receiver operating characteristic analysis. Significant differences between positive and negative sextants with respect to mean maximum SUV were calculated with a paired t test. RESULTS: Sensitivity, specificity, and accuracy were, respectively, 55%, 86%, and 67% at PET/CT; 54%, 75%, and 61% at MR imaging; and 81%, 67%, and 76% at 3D MR spectroscopy. The highest sensitivity was obtained when either 3D MR spectroscopic or MR imaging results were positive (88%) at the expense of specificity (53%), while the highest specificity was obtained when results with both techniques were positive (90%) at the expense of sensitivity (48%). Concordance between 3D MR spectroscopic and PET/CT findings was slight (kappa=0.139). CONCLUSION: In localizing cancer within the prostate, comparable specificity was obtained with either 3D MR spectroscopy and MR imaging or PET/CT; however, PET/CT had lower sensitivity relative to 3D MR spectroscopy alone or combined with MR imaging. |
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Authors:
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Claudia Testa; Riccardo Schiavina; Raffaele Lodi; Eugenio Salizzoni; Barbara Corti; Mohsen Farsad; John Kurhanewicz; Fabio Manferrari; Eugenio Brunocilla; Caterina Tonon; Nino Monetti; Paolo Castellucci; Stefano Fanti; Manuela Coe; Walter F Grigioni; Giuseppe Martorana; Romeo Canini; Bruno Barbiroli |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-07-24 |
Journal Detail:
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Title: Radiology Volume: 244 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-21 Completed Date: 2007-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 797-806 Citation Subset: AIM; IM |
Copyright Information:
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Copyright (c) RSNA, 2007. |
Affiliation:
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Department of Clinical Medicine and Applied Biotechnology D. Campanacci, Diagnostic Imaging Section V. Bollini, Pathologic Anatomy Unit, Institute of Oncology F. Addarii, P.E.T. Center, Policlinico S. Orsola-Malpighi, University of Bologna, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biopsy Carbon Radioisotopes / diagnostic use Choline / diagnostic use Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged Positron-Emission Tomography Prostatectomy Prostatic Neoplasms / diagnosis*, pathology, surgery Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 62-49-7/Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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