Document Detail

Prostate cancer diagnosed in spinal cord-injured patients is more commonly advanced stage than in able-bodied patients.
MedLine Citation:
PMID:  15028447     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the incidence and characteristics of prostate cancer in men with spinal cord injury (SCI). Little is known about the characteristics of prostate cancer in men with SCI, because prostate cancer screening is not aggressively performed in this population. METHODS: In one fiscal year, 648 men with SCI older than age 50 years were actively enrolled with the SCI service, 20,949 able-bodied men older than age 50 years were actively enrolled in the outpatient clinic database, and 945 patients with prostate cancer were in the cancer registry at our facility. These three databases were cross-referenced for prostate cancer diagnosis and stage and compared with the presence of SCI. RESULTS: Of the 648 patients with SCI, 12 patients with a prostate cancer diagnosis that preceded their injury were excluded. Of the remaining 636 patients, 11 (1.7%) had been diagnosed with prostate cancer since their injury. In contrast, of the 20,949 able-bodied men older than age 50 years seen at our facility in fiscal year 1999, 919 (4.4%) had prostate cancer. Of the patients with SCI and prostate cancer, 7 (63.6%) had locally advanced (Stage T3) or metastatic prostate cancer compared with 267 (29.1%) in the able-bodied population (P = 0.012). CONCLUSIONS: Although the proportion of patients with a prostate cancer diagnosis was greater in the able-bodied patients, the prostate cancer detected in the patients with SCI tended to be of a more advanced stage and grade. The difference was likely a result of the decreased use of prostate cancer screening in this population.
Paul A Scott; Inder Perkash; Donald Mode; Victoria A Wolfe; Martha K Terris
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Urology     Volume:  63     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-18     Completed Date:  2004-06-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-12     Citation Subset:  IM    
Section of Urology, Medical College of Georgia, Augusta, Georgia 30912-4050, USA.
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MeSH Terms
Adenocarcinoma / complications*,  epidemiology,  pathology,  psychology,  therapy
Androgens* / blood,  deficiency
Antineoplastic Agents, Hormonal / therapeutic use
Combined Modality Therapy
Erectile Dysfunction / etiology
Life Expectancy
Mass Screening
Middle Aged
Neoplasms, Hormone-Dependent / complications*,  diagnosis,  epidemiology,  pathology
Prostatic Neoplasms / complications*,  epidemiology,  pathology,  psychology,  therapy
Quality of Life
Radioisotope Teletherapy
Retrospective Studies
Spinal Cord Injuries / blood,  complications*,  psychology
Treatment Outcome
United States / epidemiology
Urination Disorders / etiology
Reg. No./Substance:
0/Androgens; 0/Antineoplastic Agents, Hormonal

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