| Prostate cancer cell phenotypes based on AGR2 and CD10 expression. | |
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MedLine Citation:
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PMID: 23348903 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The combination of expression patterns of AGR2 (anterior gradient 2) and CD10 by prostate cancer provided four phenotypes that correlated with clinical outcome. Based on immunophenotyping, CD10(low)AGR2(high), CD10(high)AGR2(high), CD10(low)AGR2(low), and CD10(high)AGR2(low) were distinguished. AGR2(+) tumors were associated with longer recurrence-free survival and CD10(+) tumors with shorter recurrence-free survival. In high-stage cases, the CD10(low)AGR2(high) phenotype was associated with a ninefold higher recurrence-free survival than the CD10(high)AGR2(low) phenotype. The CD10(high)AGR2(high) and CD10(low)AGR2(low) phenotypes were intermediate. The CD10(high)AGR2(low) phenotype was most frequent in high-grade primary tumors. Conversely, bone and other soft tissue metastases, and derivative xenografts, expressed more AGR2 and less CD10. AGR2 protein was readily detected in tumor metastases. The CD10(high)AGR2(low) phenotype in primary tumors is predictive of poor outcome; however, the CD10(low)AGR2(high) phenotype is more common in metastases. It appears that AGR2 has a protective function in primary tumors but may have a role in the distal spread of tumor cells.Modern Pathology advance online publication, 25 January 2013; doi:10.1038/modpathol.2012.238. |
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Authors:
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Melissa E Ho; Sue-Ing Quek; Lawrence D True; Colm Morrissey; Eva Corey; Robert L Vessella; Ruth Dumpit; Peter S Nelson; Erin L Maresh; Vei Mah; Mohammed Alavi; Sara R Kim; Lora Bagryanova; Steve Horvath; David Chia; Lee Goodglick; Alvin Y Liu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-25 |
Journal Detail:
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Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Volume: - ISSN: 1530-0285 ISO Abbreviation: Mod. Pathol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8806605 Medline TA: Mod Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1] Department of Urology, University of Washington, Seattle, WA, USA [2] Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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