| Prostaglandins with antiproliferative activity induce the synthesis of a heat shock protein in human cells. | |
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MedLine Citation:
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PMID: 2813398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostaglandins (PGs) A1 and J2 were found to potently suppress the proliferation of human K562 erythroleukemia cells and to induce the synthesis of a 74-kDa protein (p74) that was identified as a heat shock protein related to the major 70-kDa heat shock protein group. p74 synthesis was stimulated at doses of PGA1 and PGJ2 that inhibited cell replication, and its accumulation ceased upon removal of the PG-induced proliferation block. PGs that did not affect K562 cell replication did not induce p74 synthesis. p74 was found to be localized mainly in the cytoplasm of PG-treated cells, but moderate amounts were found also in dense areas of the nucleus after PGJ2 treatment. p74 synthesis was not necessarily associated with cytotoxicity or with inhibition of cell protein synthesis. The results described support the hypothesis that synthesis of the 70-kDa heat shock proteins is associated with changes in cell proliferation. The observation that PGs can induce the synthesis of heat shock proteins expands our understanding of the mechanism of action of these compounds whose regulatory role is well known in many physiological phenomena, including the control of fever production. |
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Authors:
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M G Santoro; E Garaci; C Amici |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 86 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1989 Nov |
Date Detail:
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Created Date: 1989-12-08 Completed Date: 1989-12-08 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 8407-11 Citation Subset: IM |
Affiliation:
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Institute of Experimental Medicine, Consiglio Nazionale delle Ricerche, Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Heat-Shock Proteins / biosynthesis*, isolation & purification Humans Immunoblotting Leukemia, Myelogenous, Chronic, BCR-ABL Positive Methionine / metabolism Molecular Weight Neoplasm Proteins / biosynthesis, isolation & purification Prostaglandins / pharmacology* Prostaglandins A / pharmacology Tumor Cells, Cultured / cytology*, drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Heat-Shock Proteins; 0/Neoplasm Proteins; 0/Prostaglandins; 0/Prostaglandins A; 14152-28-4/prostaglandin A1; 63-68-3/Methionine |
| Comments/Corrections | |
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