Document Detail

Prostaglandins and vasoactive amines in cerebral vasospasm after aneurysmal subarachnoid hemorrhage.
MedLine Citation:
PMID:  2465585     Owner:  NLM     Status:  MEDLINE    
Five consecutively admitted patients with aneurysmal subarachnoid hemorrhage were treated with an indwelling lumbar spinal catheter. Daily samples of cerebrospinal fluid were analyzed for erythrocyte, protein, glucose, dopamine, epinephrine, serotonin, 5-hydroxyindoleacetic acid, tryptophan, histamine, thromboxane, 6-ketoprostaglandin F1 alpha, prostaglandin E, and prostaglandin F2 alpha concentrations. The patients' neurologic grade on admission, hospital course, presence of vasospasm, level of consciousness, computed tomographic and angiographic findings, and outcome were compared with the concentrations of the above substances in the cerebrospinal fluid. All patients had elevated concentrations of serotonin, with the highest levels found early in the hospital course of the patients who developed vasospasm. Tryptophan content increased markedly in association with clinical and angiographic vasospasm. Concentrations of prostaglandin F2 alpha correlated highly with development of and fluctuations in clinical vasospasm, with angiographic findings, with neurologic grade on admission, and with outcome. Our results suggest that prostaglandin F2 alpha may be involved in delayed clinical vasospasm in patients with subarachnoid hemorrhage.
B B Chehrazi; S Giri; R M Joy
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  20     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-04-03     Completed Date:  1989-04-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-24     Citation Subset:  IM    
Department of Neurological Surgery, School of Medicine, University of California, Davis, Sacramento 95817.
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MeSH Terms
Cerebrospinal Fluid Proteins / analysis
Erythrocyte Count
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Intracranial Aneurysm / cerebrospinal fluid*
Ischemic Attack, Transient / cerebrospinal fluid*
Middle Aged
Prostaglandins / cerebrospinal fluid*
Serotonin / cerebrospinal fluid*
Subarachnoid Hemorrhage / cerebrospinal fluid*
Tryptophan / cerebrospinal fluid*
Reg. No./Substance:
0/Cerebrospinal Fluid Proteins; 0/Prostaglandins; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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