Document Detail

Prostaglandins and otitis media: studies in the chinchilla.
MedLine Citation:
PMID:  7402673     Owner:  NLM     Status:  MEDLINE    
Prostaglandins (PG) are naturally occurring, cyclic, unsaturated fatty acids that possess a wide range of potent biologic activities. Prostaglandins have been found in human middle ear effusions and may have implications for understanding the inflammation and, possibly, the bone resorption seen in chronic otitis media. In the study presented, PGs were measured by radioimmuno-assay in middle ear effusions from experimentally induced serous and purulent otitis media in chinchillas. The ability of chinchilla middle ear mucosa to synthesize PGs from 14C-arachidonic acid was also demonstrated. The authors suggest an active role for PGs in the inflammation and the bone resorption seen in otitis media.
T T Jung; D M Smith; S K Juhn; J M Gerrard
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Otolaryngology and head and neck surgery     Volume:  88     ISSN:  -     ISO Abbreviation:  Otolaryngol. Head Neck Surg.     Publication Date:    1980 May-Jun
Date Detail:
Created Date:  1980-10-21     Completed Date:  1980-10-21     Revised Date:  2012-04-25    
Medline Journal Info:
Nlm Unique ID:  7909794     Medline TA:  Otolaryngol Head Neck Surg (1979)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  316-23     Citation Subset:  IM    
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MeSH Terms
Acid Phosphatase / analysis
Alkaline Phosphatase / analysis
Arachidonic Acids / metabolism
Ear, Middle / metabolism*
L-Lactate Dehydrogenase / analysis
Mucous Membrane / metabolism
Otitis Media / etiology*
Prostaglandins / biosynthesis,  pharmacology*
Prostaglandins E / administration & dosage,  metabolism,  pharmacology
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins; 0/Prostaglandins E; EC Dehydrogenase; EC Phosphatase; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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