Document Detail

Prostaglandins and modulation of small bowel myoelectric activity.
MedLine Citation:
PMID:  1347976     Owner:  NLM     Status:  MEDLINE    
We explored the effects of prostaglandins (PG) F2 alpha and E2 on the motor and myoelectric activity of the small intestine using closed intra-arterial injections in conscious chronically instrumented dogs. PGF2 alpha (0.125-5 micrograms) and PGE2 (1-10 micrograms) were injected via a T tube into a branch of the superior mesenteric artery perfusing a 15-cm segment of jejunum. Experiments were performed on four dogs in which the recording devices had been implanted above, below, and within the perfused segment. PGF2 alpha given during phase I of the migrating myoelectric complex cycle induced phasic contractions in the perfused segment of intestine in a dose-dependent manner. Atropine (50-100 micrograms), hexamethonium (15 mg), or TTX (10-15 micrograms) administered before the injection of PGF2 alpha failed to inhibit the effects of PGF2 alpha. In contrast pretreatment of the perfused segment with verapamil (2.5 mg) or PGE2 (1-5 micrograms) abolished the effects of PGF2 alpha. Moreover, PGE2 injected 5 min after the administration of PGF2 alpha inhibited the PGF2 alpha-induced contractions. Administration of PGE2 alone (3-10 micrograms) before the arrival of phase III activity in the perfused segment abolished phase III from this segment of intestine. Our studies indicate opposing effects of PGF2 alpha and PGE2 on small intestinal myoelectric and contractile activities. PGF2 alpha has a direct excitatory effect on the intestinal smooth muscle, which is calcium channel dependent but independent of intrinsic nerves. PGE2 has an inhibitory effect both on the spontaneous and PGF2 alpha-induced small intestinal myoelectric and contractile activity.
C T Frantzides; E A Lianos; D Wittmann; B Greenwood; C E Edmiston
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  262     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-23     Completed Date:  1992-04-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G488-97     Citation Subset:  IM    
Department of Surgery, Medical College of Wisconsin, Milwaukee 53226.
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MeSH Terms
Atropine / pharmacology
Dinoprost / physiology*
Dinoprostone / physiology*
Electromyography / drug effects
Gastrointestinal Motility / drug effects,  physiology*
Hexamethonium Compounds / pharmacology
Intestine, Small / drug effects,  physiology*
Muscle, Smooth / drug effects,  physiology*
Tetrodotoxin / pharmacology
Verapamil / pharmacology
Grant Support
Reg. No./Substance:
0/Hexamethonium Compounds; 363-24-6/Dinoprostone; 4368-28-9/Tetrodotoxin; 51-55-8/Atropine; 52-53-9/Verapamil; 551-11-1/Dinoprost; 60-26-4/Hexamethonium

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