| Prostaglandins and menorrhagia. | |
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MedLine Citation:
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PMID: 6344539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper reviews the various theories offered to explain excessive menstrual blood losses whether these are of primary origin or induced by IUD. An increased concentration of prostaglandins in endometrial tissue at the onset of menstruation may contribute to heavy menstrual bleeding. The mechanism of action is not clear, but prostaglandins may affect the stability of lysosomes which in turn lead to increased release of various proteinases. These in turn may disturb the hemostatic mechanism of the endometrium. Prostaglandins may also affect platelet aggregation and/or various coagulation factors and cause vasodilation - all mechanisms may theoretically alter the hemostasis of the endometrium. Treatment of menorrhagia with a prostaglandin synthetase inhibitor, naproxen, resulted in a significant reduction in menstrual blood loss in women with primary menorrhagia as well as with IUD-induced excessive menstrual blood loss. The reduction amounted to about 30%, which is lower than the reduction obtained by treatment with antifibrinolytic agents or oral contraceptives. |
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Authors:
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K G Nygren; G Rybo |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica. Supplement Volume: 113 ISSN: 0300-8835 ISO Abbreviation: Acta Obstet Gynecol Scand Suppl Publication Date: 1983 |
Date Detail:
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Created Date: 1983-07-08 Completed Date: 1983-07-08 Revised Date: 2008-02-21 |
Medline Journal Info:
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Nlm Unique ID: 0337655 Medline TA: Acta Obstet Gynecol Scand Suppl Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 101-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antifibrinolytic Agents
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therapeutic use Clinical Trials as Topic Contraceptives, Oral / therapeutic use Female Humans Intrauterine Devices / adverse effects* Menorrhagia / drug therapy, etiology, physiopathology* Naproxen / therapeutic use* Prostaglandins / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antifibrinolytic Agents; 0/Contraceptives, Oral; 0/Prostaglandins; 22204-53-1/Naproxen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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