Document Detail

Prostaglandins, inflammation, and preterm labor.
MedLine Citation:
PMID:  2496208     Owner:  NLM     Status:  MEDLINE    
According to the current view, the fetal membranes and the amniotic fluid are central in transmission of signals resulting in labor and delivery. It has also become increasingly evident that although preterm and term labor share common pathways in activation of uterine contractions, the regulatory aspects are fundamentally different. The present article is a brief overview focusing on the participation of prostaglandins in human term and preterm labor. The involvement of bacteria in preterm labor is presented. In addition, it is proposed that inflammatory polymorphonuclear leukocytes promote preterm labor by activating prostaglandin production from human fetal membranes.
K Bry; M Hallman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  9     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-06-01     Completed Date:  1989-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  60-5     Citation Subset:  IM    
Department of Pediatrics, University of Helsinki, Finland.
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / metabolism
Chorioamnionitis / complications*
Extraembryonic Membranes / metabolism
Labor Onset / physiology*
Labor, Obstetric / physiology*
Neutrophils / immunology
Obstetric Labor, Premature / etiology*
Pregnancy Complications, Infectious*
Prostaglandins / physiology*
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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