Document Detail

Prostaglandins in selected reproductive tissues in preterm and full-term gestations.
MedLine Citation:
PMID:  8981626     Owner:  NLM     Status:  MEDLINE    
We investigated differences in maternal plasma and trophoblast prostaglandin metabolism associated with preterm births. Tissue prostaglandins (PGs) E2 and F2 alpha and the stable plasma PGF2 alpha metabolite, 13,14-dihydro-15-keto-PGF2 alpha, were measured in preterm (< 37 weeks) and term (< or = 37 weeks) births. Amnion PGE2 in preterm (106.1 +/- 15.7 ng/g wet weight tissue; x +/- SEM; n = 37) was lower than in term (176.6 +/- 22.7 ng/g wet weight; x +/- SEM; n = 34, P < 0.02). Placenta PGE2 was lower in preterm (34.7 +/- 19.7 ng/g wet weight; x +/- SEM) than in term (103.3 +/- 28.0 ng/g wet weight; x +/- SEM, P < 0.04). Preterm PGF2 alpha was consistently lower in the amnion (106.8 +/- 17.5 ng/g wet weight) and placenta (102.5 +/- 8.7 ng/g wet weight) than in term amnion (188.2 +/- 24.8 ng/g wet weight; P < 0.01) and placenta (128.9 +/- 7.8 ng/g wet weight; P < 0.03). Chorionic PGE2 and plasma PGF2 alpha metabolite followed this trend but did not reach significance. These findings suggest qualitative and quantitative differences in maternal and trophoblast eicosanoid metabolism between term and preterm parturition.
M S Reece; J A McGregor; K G Allen; M M Mathias; M A Harris
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  55     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-21     Completed Date:  1997-03-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  303-7     Citation Subset:  IM    
Colorado State University, Department of Food Science and Human Nutrition, Fort Collins 80523, USA.
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MeSH Terms
Age Factors
Amnion / metabolism
Birth Weight
Body Weight
Chorion / metabolism
Dinoprost / blood,  metabolism
Dinoprostone / metabolism
Embryo, Mammalian / metabolism*
Gestational Age*
Infant, Newborn
Labor, Obstetric / metabolism*
Obstetric Labor, Premature / epidemiology,  metabolism
Placenta / metabolism
Prostaglandins / metabolism*
Reg. No./Substance:
0/Prostaglandins; 363-24-6/Dinoprostone; 551-11-1/Dinoprost
Erratum In:
Prostaglandins Leukot Essent Fatty Acids 1997 Apr;56(4):335

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