Document Detail

Prostaglandins in the plasma and amniotic fluid of rhesus monkeys during pregnancy and after intra-uterine foetal death.
MedLine Citation:
PMID:  824394     Owner:  NLM     Status:  MEDLINE    
Prostaglandin F (PGF) was measured in amniotic fluid, and 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM) was measured in maternal peripheral venous plasma and amniotic fluid of rhesus monkeys during late pregnancy. 13,14-Dihydro-15-keto-PGF2 alpha was determined in the maternal peripheral venous plasma of two animals following intra-uterine foetal death. The mean concentration of PGF and PGFM in amniotic fluid increased fourfold during the last 5 days of pregnancy. This increase was associated with an increase in the oestrone concentration in amniotic fluid and in maternal plasma. In normal pregnancy there was no increase in PGFM levels in the maternal peripheral vein, up to 1-2 days pre partum. After intra-uterine death, progesterone concentration in the maternal peripheral vein was unaltered, but oestrone and oestradiol declined. In plasma samples taken within 12 h of delivery, the concentration of PGFM was raised. It is concluded that an increase in prostaglandin production accompanies delivery at normal term, and at delivery past term following intra-uterine foetal death.
M D Mitchell; J E Patrick; J S Robinson; G D Thorburn; J R Challis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  71     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  67-76     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / metabolism*
Estradiol / blood
Estrone / blood
Fetal Death / metabolism*
Macaca mulatta
Pregnancy, Animal*
Progesterone / blood
Prostaglandins F / metabolism*
Reg. No./Substance:
0/Prostaglandins F; 50-28-2/Estradiol; 53-16-7/Estrone; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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