Document Detail

Prostaglandins and high blood pressure.
MedLine Citation:
PMID:  359239     Owner:  NLM     Status:  MEDLINE    
Prostaglandins A1, B1, E2, Falpha and PRA have been measured by radioimmunoassay in peripheral or renal venous blood of different groups of hypertensive and control subjects. PGA1 and PGE2 were significantly increased in renal, renovascular, labile and essential hypertension. PGFalpha was significantly increased only in patients with unilateral renal atrophy and in some patients with renovascular and essential hypertension. There was a significant positive correlation between PRA and PGA1 or B1, but not with PGE2 or Falpha. The increase of PGA and PGE represents a secondary antihypertensive, diuretic and natriuretic mechanism, the increase of PGF a direct hypertensive mechanism.
A Hornych
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Contributions to nephrology     Volume:  12     ISSN:  0302-5144     ISO Abbreviation:  Contrib Nephrol     Publication Date:  1978  
Date Detail:
Created Date:  1978-12-27     Completed Date:  1978-12-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7513582     Medline TA:  Contrib Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  54-68     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Hypertension / physiopathology*
Hypertension, Renal / physiopathology*
Kidney Diseases / physiopathology*
Middle Aged
Prostaglandins / blood*
Reg. No./Substance:

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