Document Detail

Prostaglandins for duodenal ulcer.
MedLine Citation:
PMID:  2887323     Owner:  NLM     Status:  MEDLINE    
Studies to date indicate that certain synthetic prostaglandin E derivatives, notably misoprostol and enprostil, possess duodenal ulcer healing efficacy that is equivalent to that of the existing H2-receptor antagonists. Whether healing is achieved by virtue of their antisecretory action alone or in combination with their cytoprotective properties cannot be ascertained. Earlier reports that non-antisecretory prostaglandin E2 was effective for duodenal-ulcer healing suggested that cytoprotective mechanisms may contribute to ulcer healing, but this needs be confirmed. Chronic cigarette smoking adversely affects duodenal ulcer healing despite treatment with potent acid-reducing regimens. Evidence is available that cigarette smoking reduces luminal prostaglandins in the stomach, and that misoprostol, a prostaglandin E1 is able to overcome the adverse effect of smoking on duodenal ulcer healing, further suggesting that cytoprotective mechanisms may contribute to ulcer healing. Furthermore, misoprostol has been shown to be the first therapeutic agent capable of improving active chronic antral gastritis, which has recently been found to be almost invariably associated with active duodenal ulcer.
S K Lam
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical and investigative medicine. Médecine clinique et experimentale     Volume:  10     ISSN:  0147-958X     ISO Abbreviation:  Clin Invest Med     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-10-20     Completed Date:  1987-10-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7804071     Medline TA:  Clin Invest Med     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  232-7     Citation Subset:  IM    
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MeSH Terms
Anti-Ulcer Agents / therapeutic use
Chronic Disease
Clinical Trials as Topic
Duodenal Ulcer / drug therapy*
Gastritis / drug therapy
Histamine H2 Antagonists / therapeutic use
Prostaglandins / therapeutic use*
Prostaglandins E / therapeutic use
Pyloric Antrum / pathology
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Histamine H2 Antagonists; 0/Prostaglandins; 0/Prostaglandins E; 363-24-6/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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