| Prostaglandins do not Contribute to the Nitric Oxide Mediated Compensatory Vasodilation in Hypoperfused Exercising Muscle. | |
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MedLine Citation:
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PMID: 21536852 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We tested the hypothesis that 1) prostaglandins (PGs) contribute to compensatory vasodilation in contracting human forearm subjected to acute hypoperfusion, and 2) the combined inhibition of PGs and nitric oxide (NO) would attenuate the compensatory vasodilation more than PG inhibition alone. In separate protocols subjects performed forearm exercise (20% of maximum) during hypoperfusion evoked by intra-arterial balloon inflation. Each trial included; baseline, exercise prior to inflation, exercise with inflation, and exercise after deflation. Forearm blood flow (FBF; ultrasound), local (brachial artery), and systemic arterial pressure (MAP; Finometer) were measured. In protocol 1 (n=8), exercise was repeated during cyclooxygenase (COX) inhibition (Ketorolac) alone and during Ketorolac/NOS inhibition (N(G)-monomethyl-L-arginine; L-NMMA). In protocol 2 (n=8), exercise was repeated during L-NMMA alone and during L-NMMA/Ketorolac. Forearm vascular conductance (FVC; ml/min/100mmHg) was calculated from FBF (ml/min) and local MAP (mmHg). The % recovery in FVC during inflation was calculated as (steady state inflation plus exercise value - nadir)/ [steady state exercise (control) value-nadir] x 100. Protocol 1: COX inhibition alone did not reduce the % FVC recovery compared to the control (no drug) trial (92±11% vs. 100±10%, P=0.83) However, combined COX/NOS inhibition caused a substantial reduction in % FVC recovery (54±8%, P<0.05 vs. Ketorolac alone). Protocol 2: The % recovery in FVC was attenuated with NOS inhibition alone (69±9% vs. 107±10%, P<0.01), but not attenuated further during combined NOS/COX inhibition (62±10%, P=0.74 vs. L-NMMA alone). Our data indicate that PGs are not obligatory to the compensatory dilation observed during forearm exercise with hypoperfusion. |
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Authors:
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Darren P Casey; Michael J Joyner |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-2 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Mayo Clinic. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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