Document Detail

Prostaglandins, antipyretic analgesics and adrenergic stimuli on the isolated artery.
MedLine Citation:
PMID:  1126367     Owner:  NLM     Status:  MEDLINE    
In untreated, and cocaine- and DOCA-treated rabbit ear arteries, PGE2 and arachidonic depressed to responses to intramural sympathetic nerve stimulation. Constrictor responses to extraluminal NA in the treated arteries were also depressed. A comparison of its inhibitory potency on the two types of responses suggest that the effects of arachidonic acid, but not PGE2 on adrenergic nerve stimuli, were selectively blocked by aspirin 200 mug/ml and by indomethacin 3 mu/ml. In these concentrations, aspirin, but not indomethacin, enhanced the magnitude of the resoonses to the stimuli. Aspirin also selectively reduced the inhibition by arachidonic acid of the response to extraluminal NA (tested in cocaine0 and DOCA-treated arteries).
I S De La Lande; R C Hall; J A Kennedy; G D Higgins
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  30     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-07-28     Completed Date:  1975-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  319-27     Citation Subset:  IM    
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MeSH Terms
8,11,14-Eicosatrienoic Acid / pharmacology
Analgesics / pharmacology*
Arachidonic Acids / pharmacology
Arteries / drug effects*
Aspirin / pharmacology
Cocaine / pharmacology
Electric Stimulation
Indomethacin / pharmacology
Norepinephrine / pharmacology
Prostaglandins / pharmacology*
Sympathetic Nervous System / physiology*
Reg. No./Substance:
0/Analgesics; 0/Arachidonic Acids; 0/Prostaglandins; 50-36-2/Cocaine; 50-78-2/Aspirin; 51-41-2/Norepinephrine; 53-86-1/Indomethacin; 7324-41-6/8,11,14-Eicosatrienoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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