Document Detail


Prostaglandins and radical oxygen species are involved in microvascular effects of hyperoxia.
MedLine Citation:
PMID:  20145417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperoxia causes vasoconstriction in most tissues, by mechanisms that are not fully understood. We investigated microvascular effects of breathing 100% oxygen in healthy volunteers, using iontophoresis to deliver acetylcholine (ACh) and sodium nitroprusside (SNP). Aspirin and vitamin C were used to test for involvement of prostaglandins and radical oxygen species. Forearm skin perfusion was measured using laser Doppler perfusion imaging. Results were analysed using dose-response modelling. The response to ACh was reduced by 30% during oxygen breathing compared to air breathing [0.98 (0.81-1.15) PU vs. 1.45 (1.30-1.60) PU, p < 0.001]. ED(50) values were unchanged [2.25 (1.84-2.75) vs. 2.21 (1.79-2.74), not significant]. Aspirin pre-treatment abolished the difference in response between oxygen breathing and air breathing [maximum: 1.03 (0.90-1.16) vs. 0.89 (0.77-1.01), not significant; ED(50): 1.83 (1.46-2.30) vs. 1.95 (1.65-2.30), not significant]. ACh-mediated vasodilatation during 100% oxygen breathing was partially restored after pre-treatment with vitamin C. Breathing 100% oxygen did not change the microvascular response to SNP [1.45 (1.28-1.62) vs. 1.40 (1.26-1.53), not significant]. These results favour the hypothesis that hyperoxic vasoconstriction is mediated by inhibition of prostaglandin synthesis. Radical oxygen species may be involved as vitamin C, independently of aspirin, partially restored ACh-mediated vasodilatation during hyperoxia.
Authors:
A Rousseau; E Tesselaar; J Henricson; F Sjöberg
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Publication Detail:
Type:  Journal Article     Date:  2010-02-10
Journal Detail:
Title:  Journal of vascular research     Volume:  47     ISSN:  1423-0135     ISO Abbreviation:  J. Vasc. Res.     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-19     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  441-50     Citation Subset:  IM    
Affiliation:
Departments of Medicine and Health Sciences, Linköping University, Linköping, Sweden. andreas.rousseau@lio.se
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Adult
Ascorbic Acid / pharmacology
Aspirin / pharmacology
Dose-Response Relationship, Drug
Female
Forearm / blood supply
Humans
Hyperoxia / physiopathology*
Laser-Doppler Flowmetry
Male
Nitroprusside / pharmacology
Oxygen / pharmacology
Prostaglandins / biosynthesis,  physiology*
Reactive Oxygen Species / pharmacology
Regional Blood Flow / drug effects
Vasoconstriction / physiology
Vasodilation / drug effects
Chemical
Reg. No./Substance:
0/Prostaglandins; 0/Reactive Oxygen Species; 15078-28-1/Nitroprusside; 50-78-2/Aspirin; 50-81-7/Ascorbic Acid; 51-84-3/Acetylcholine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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