| Prostaglandins, H2-receptor antagonists and peptic ulcer disease. | |
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MedLine Citation:
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PMID: 2905237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peptic ulcer develops when offensive factors overwhelm defensive processes in the gastroduodenal mucosa. Offensive factors include NSAIDs, hydrochloric acid-peptic activity, bile reflux, and some products of the lipoxygenase pathway such as leukotriene B4; whereas defensive processes are largely mediated by prostaglandins through poorly understood mechanisms uniformly termed cytoprotection. Cytoprotection, a physiological process working through the products of arachidonic acid metabolism, may result from the net effect of the protective actions of prostaglandins versus the damaging actions of leukotrienes. Some prostaglandins also have antisecretory effects. Therefore the peptic ulcer healing effects of prostaglandin analogues, all of which have significant antisecretory activity, may be more due to their antisecretory effects than primarily to their effects on mucosal defences. Certain drug-induced gastroduodenal lesions, e.g. NSAID-induced ulcers, which are often unresponsive to H2-receptor antagonists, have been healed and their recurrence prevented by the use of PGE1 and PGE2 analogues. All the prostaglandin analogues investigated to date in humans have the potential for inducing abortion, an important side effect which may limit their worldwide use. The optimal prostaglandin analogue for ulcer healing should not induce abortion and should be potently cytoprotective. The predominant damaging agent in the development of peptic ulcer disease is gastric hydrochloric acid. Thus, the worldwide established efficacy and safety of H2-receptor antagonists such as cimetidine, ranitidine, famotidine and most recently of roxatidine acetate suggest that these agents have become the standard by which other forms of anti-ulcer therapy should be judged. |
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Authors:
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P Bright-Asare; T Habte; B Yirgou; J Benjamin |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drugs Volume: 35 Suppl 3 ISSN: 0012-6667 ISO Abbreviation: Drugs Publication Date: 1988 |
Date Detail:
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Created Date: 1989-02-14 Completed Date: 1989-02-14 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7600076 Medline TA: Drugs Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Affiliation:
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Digestive Diseases Research Center, King/Drew Medical Center, Los Angeles. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Histamine H2 Antagonists
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therapeutic use* Humans Peptic Ulcer / drug therapy*, physiopathology Prostaglandins / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Histamine H2 Antagonists; 0/Prostaglandins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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