Document Detail

Prostaglandin synthesis inhibitor affects humoral conditions and oxygen metabolism during normothermic cardiopulmonary bypass.
MedLine Citation:
PMID:  12139494     Owner:  NLM     Status:  MEDLINE    
We have reported that infusion of prostaglandin synthesis inhibitor (PGSI) reduced the severity of hypotension during normothermic cardiopulmonary bypass (CPB). In the present study, we investigated the effects of PGSI on humoral conditions and whole body oxygen metabolism during normothermic CPB conducted for 60 min in 8 adult goats. The PGSI group (n = 4) was administered 100 to 150 mg of flurbiprofen, a potent PGSI, before and during CPB, and the control group (n = 4) was administered noradrenaline (NA) to restore hypotension. The prostaglandin E2 (PGE2) and NA concentrations in the PGSI group were significantly lower than those of the control group (PGE2 8.8 +/- 1.0 versus 30.3 +/- 11.5 pg/ml, NA 431 +/- 197 versus 3847 +/- 2,153 pg/ml). The adrenaline concentration was not significantly different between the groups. The oxygen consumption and the oxygen extraction rate were not significantly different between the groups, but the blood lactate level in the PGSI group was lower than that of the control group (34.3 +/- 7.6 versus 43.7 +/- 3.8 mg/dl). In conclusion, PGSI improves humoral disorder and thus prevents inadequate tissue oxygen delivery.
Yoshiaki Takewa; Yoshiyuki Taenaka; Eisuke Tatsumi; Koichi Sato; Hiroyuki Ohnishi; Mitsuo Oshikawa; Tomohiro Nishinaka; Hisateru Takano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  26     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-25     Completed Date:  2002-10-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  676-81     Citation Subset:  IM    
Department of Artificial Organs, national Cardiovascular Center Research Institute, Oasaka, Japan.
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MeSH Terms
Analysis of Variance
Cardiopulmonary Bypass / adverse effects*
Cyclooxygenase Inhibitors / pharmacology*
Dinoprostone / biosynthesis
Flurbiprofen / pharmacology*
Hypotension / drug therapy*,  etiology
Norepinephrine / pharmacology
Oxygen / metabolism
Oxygen Consumption / drug effects*
Vasoconstrictor Agents / pharmacology
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Vasoconstrictor Agents; 363-24-6/Dinoprostone; 51-41-2/Norepinephrine; 5104-49-4/Flurbiprofen; 7782-44-7/Oxygen

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