| Prostaglandin synthesis inhibition and postprandial intestinal hyperemia. | |
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MedLine Citation:
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PMID: 7065141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of prostaglandin synthesis inhibition on the postprandial intestinal hyperemia was examined in the jejunum of anesthetized dogs. Both intravenous and intra-arterial infusion of the cyclooxygenase inhibitors indomethacin and mefenamic acid reduced resting jejunal blood flow and markedly enhanced the food-induced jejunal hyperemia. The jejunal vascular response to food did not change after either intravenous or intra-arterial infusion of the carrier solutions or intra-arterial infusion of angiotensin II. The enhancement of the jejunal hyperemia was associated with an increase in the food-induced increase in jejunal oxygen consumption. Infusion of the cyclooxygenase inhibitors increased the mean amplitude of the monophasic intestinal contractions; however, this did not appear to play a role in the enhancement of the food-induced hyperemia. The study indicates that inhibition of prostaglandin synthesis has a marked effect on the postprandial intestinal hyperemia and that this may be due to its enhancement of the jejunal metabolic response to food. The prostaglandins involved and their mechanism of action are unknown. |
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Authors:
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R H Gallavan; C C Chou |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 242 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1982 Feb |
Date Detail:
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Created Date: 1982-05-21 Completed Date: 1982-05-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G140-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Feeding Behavior / physiology* Female Hyperemia / physiopathology Indomethacin / pharmacology* Jejunum / blood supply* Male Mefenamic Acid / pharmacology* Prostaglandin Antagonists / pharmacology Prostaglandins / physiology Regional Blood Flow / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL-15231/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandin Antagonists; 0/Prostaglandins; 53-86-1/Indomethacin; 61-68-7/Mefenamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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