Document Detail

Prostaglandin synthesis by rat uterine homogenates in the presence of copper ions, and the effects of indomethacin and salicylic acid.
MedLine Citation:
PMID:  3456618     Owner:  NLM     Status:  MEDLINE    
While no significant effects on the in vitro production of PGF2 alpha by homogenates of rat estrous uteri were observed in the presence of 10(-3) and 10(-6) M Cu2+, the presence of Cu2+ at 10(-4) and 10(-5) M was found to stimulate production with maximal synthesis of PGF2 alpha occurring with 10(-4) M Cu2+. By contrast, the synthesis of PGE2 and PGI2 (determined as 6-keto PGF1 alpha) were unaffected at all of the different Cu2+ concentration used. When indomethacin and salicylic acid were tested for their effects on the Cu2+-mediated levels of PG synthesis by the homogenates, indomethacin (at 20 microM) was found to cause similar pronounced decreases in PGF2 alpha, PGE2 and 6-keto PGF1 alpha whereas salicylic acid (400 microM) showed preference towards suppressing PGE2 and 6-keto PGF1 alpha production.
P V Peplow; P R Hurst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and medicine     Volume:  21     ISSN:  0262-1746     ISO Abbreviation:  Prostaglandins Leukot Med     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-11     Completed Date:  1986-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206868     Medline TA:  Prostaglandins Leukot Med     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  15-22     Citation Subset:  IM    
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MeSH Terms
Copper / pharmacology*
Indomethacin / pharmacology*
Prostaglandins / biosynthesis*
Prostaglandins F / biosynthesis
Rats, Inbred Strains
Salicylic Acid
Salicylic Acids / pharmacology*
Uterus / drug effects,  metabolism*
Reg. No./Substance:
0/Prostaglandins; 0/Prostaglandins F; 0/Salicylic Acids; 53-86-1/Indomethacin; 551-11-1/Dinoprost; 69-72-7/Salicylic Acid; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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